Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients
Introduction. Patients with moderate and severe COVID-19 generally receive antibiotic therapy with consideration of the possibility of co-infection or secondary bacterial infection which clinically is difficult to distinguish from COVID-19 symptoms. Overuse of antibiotics can lead to an increased ri...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2022-12-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | https://scholarhub.ui.ac.id/jpdi/vol9/iss4/19/ |
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| author | Lie Khie Chen Jason Nathanael Sharifah Shakinah Adeline Pasaribu Robert Sinto Leonard Nainggolan Adityo Susilo |
| author_facet | Lie Khie Chen Jason Nathanael Sharifah Shakinah Adeline Pasaribu Robert Sinto Leonard Nainggolan Adityo Susilo |
| author_sort | Lie Khie Chen |
| collection | DOAJ |
| description | Introduction. Patients with moderate and severe COVID-19 generally receive antibiotic therapy with consideration of the possibility of co-infection or secondary bacterial infection which clinically is difficult to distinguish from COVID-19 symptoms. Overuse of antibiotics can lead to an increased risk of bacterial resistance to antibiotics which is associated with poor outcomes in COVID-19 patients. This study aimed to assess the effect of early antibiotic administration on mortality in moderate and severe COVID-19 patients. Methods. An observational study with a retrospective cohort design was conducted at Dr. Cipto Mangunkusumo Hospital. Data were obtained from medical records of patients admitted from March to September 2020. Patients who received early antibiotics were defined as patients who received antibiotics hospital, 108 subjects were included in this study, 74 (68.5%) with moderate degrees and 34 (31.5%) with severe degrees. Early antibiotics were administered to 79 (73.1%) subjects with a median start time of one day. The results of the bivariate analysis did not find a significant effect of early antibiotic administration on mortality in moderate or severe COVID-19 patients (p=0.42). Subgroup analysis based on the degree of disease also found no significant results. Conclusion. There is no relationship between early antibiotic administration and mortality of moderate and severe COVID-19 patients. |
| format | Article |
| id | doaj-art-67d3a78a054946378eee5bc5d1f5dec5 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2022-12-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-67d3a78a054946378eee5bc5d1f5dec52025-08-20T02:23:04ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212022-12-0194189193https://doi.org/10.7454/jpdi.v9i4.1019Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 PatientsLie Khie Chen0Jason Nathanael1Sharifah Shakinah2Adeline Pasaribu3Robert Sinto4Leonard Nainggolan5Adityo Susilo61. Divisi Penyakit Tropik dan Infeksi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta 2. Komite Program Pengendalian Resistensi Antimikroba, RSUPN Dr. Cipto Mangunkusumo, JakartaFakultas Kedokteran Universitas IndonesiaDivisi Penyakit Tropik dan Infeksi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Penyakit Tropik dan Infeksi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta1. Divisi Penyakit Tropik dan Infeksi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta 2. Komite Program Pengendalian Resistensi Antimikroba, RSUPN Dr. Cipto Mangunkusumo, Jakarta1. Divisi Penyakit Tropik dan Infeksi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta 2. Komite Program Pengendalian Resistensi Antimikroba, RSUPN Dr. Cipto Mangunkusumo, Jakarta1. Divisi Penyakit Tropik dan Infeksi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta 2. Komite Program Pengendalian Resistensi Antimikroba, RSUPN Dr. Cipto Mangunkusumo, JakartaIntroduction. Patients with moderate and severe COVID-19 generally receive antibiotic therapy with consideration of the possibility of co-infection or secondary bacterial infection which clinically is difficult to distinguish from COVID-19 symptoms. Overuse of antibiotics can lead to an increased risk of bacterial resistance to antibiotics which is associated with poor outcomes in COVID-19 patients. This study aimed to assess the effect of early antibiotic administration on mortality in moderate and severe COVID-19 patients. Methods. An observational study with a retrospective cohort design was conducted at Dr. Cipto Mangunkusumo Hospital. Data were obtained from medical records of patients admitted from March to September 2020. Patients who received early antibiotics were defined as patients who received antibiotics hospital, 108 subjects were included in this study, 74 (68.5%) with moderate degrees and 34 (31.5%) with severe degrees. Early antibiotics were administered to 79 (73.1%) subjects with a median start time of one day. The results of the bivariate analysis did not find a significant effect of early antibiotic administration on mortality in moderate or severe COVID-19 patients (p=0.42). Subgroup analysis based on the degree of disease also found no significant results. Conclusion. There is no relationship between early antibiotic administration and mortality of moderate and severe COVID-19 patients.https://scholarhub.ui.ac.id/jpdi/vol9/iss4/19/early antibioticsmoderate and severe covid-19mortality |
| spellingShingle | Lie Khie Chen Jason Nathanael Sharifah Shakinah Adeline Pasaribu Robert Sinto Leonard Nainggolan Adityo Susilo Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients Jurnal Penyakit Dalam Indonesia early antibiotics moderate and severe covid-19 mortality |
| title | Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients |
| title_full | Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients |
| title_fullStr | Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients |
| title_full_unstemmed | Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients |
| title_short | Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients |
| title_sort | association between early antibiotic administration and in hospital mortality in moderate and severe covid 19 patients |
| topic | early antibiotics moderate and severe covid-19 mortality |
| url | https://scholarhub.ui.ac.id/jpdi/vol9/iss4/19/ |
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