Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
Metastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the b...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/917581 |
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| author | Clément Dumont Hélène Gauthier Jérôme Vérine Jacqueline Lehmann-Che Patricia de Cremoux Damien Pouessel Stéphane Culine |
| author_facet | Clément Dumont Hélène Gauthier Jérôme Vérine Jacqueline Lehmann-Che Patricia de Cremoux Damien Pouessel Stéphane Culine |
| author_sort | Clément Dumont |
| collection | DOAJ |
| description | Metastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the breast. The diagnosis of breast metastasis was aided by identity of pathology, immunochemistry, and molecular biology findings between the primary tumor and the breast lesion, among which are the p.K120M mutation, a very rare TP53 mutation, and HER2 overexpression with underlying polysomy of chromosome 17. |
| format | Article |
| id | doaj-art-67cf6db6f70345efa77a052a2932c385 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-67cf6db6f70345efa77a052a2932c3852025-08-20T03:33:50ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/917581917581Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?Clément Dumont0Hélène Gauthier1Jérôme Vérine2Jacqueline Lehmann-Che3Patricia de Cremoux4Damien Pouessel5Stéphane Culine6Department of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceDepartment of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceDepartment of Pathology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceMolecular Oncology Unit, Department of Biochemistry, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceMolecular Oncology Unit, Department of Biochemistry, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceDepartment of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceDepartment of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, FranceMetastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the breast. The diagnosis of breast metastasis was aided by identity of pathology, immunochemistry, and molecular biology findings between the primary tumor and the breast lesion, among which are the p.K120M mutation, a very rare TP53 mutation, and HER2 overexpression with underlying polysomy of chromosome 17.http://dx.doi.org/10.1155/2014/917581 |
| spellingShingle | Clément Dumont Hélène Gauthier Jérôme Vérine Jacqueline Lehmann-Che Patricia de Cremoux Damien Pouessel Stéphane Culine Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? Case Reports in Oncological Medicine |
| title | Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? |
| title_full | Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? |
| title_fullStr | Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? |
| title_full_unstemmed | Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? |
| title_short | Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? |
| title_sort | concomitant bifocal urothelial carcinoma and breast tumor second primary cancer or metastatic spread to the breast |
| url | http://dx.doi.org/10.1155/2014/917581 |
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