Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab
Penetrating aortic ulcers are uncommon and life-threatening. We describe the case of a 67-year-old man who presented with fever and chills and was found on computed tomographic scan to have a thoracic penetrating aortic ulcer. The patient underwent placement of a thoracic branch endoprosthesis, with...
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Elsevier
2025-08-01
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| Series: | Journal of Vascular Surgery Cases and Innovative Techniques |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468428725001194 |
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| author | Sarah Kim, BA Patrick D. Conroy, MD Mark Zemela, MD Bruce L. Tjaden, Jr., MD |
| author_facet | Sarah Kim, BA Patrick D. Conroy, MD Mark Zemela, MD Bruce L. Tjaden, Jr., MD |
| author_sort | Sarah Kim, BA |
| collection | DOAJ |
| description | Penetrating aortic ulcers are uncommon and life-threatening. We describe the case of a 67-year-old man who presented with fever and chills and was found on computed tomographic scan to have a thoracic penetrating aortic ulcer. The patient underwent placement of a thoracic branch endoprosthesis, with a postoperative course complicated by ileocolic pseudoaneurysm, progressive aortitis, and a fatal aortoesophageal fistula. The management of penetrating aortic ulcer in the setting of multiple confounding factors is discussed in the context of this patient’s complex medical presentation, with a focus on the potential role of pembrolizumab in his disease progression. |
| format | Article |
| id | doaj-art-67cbd4b5b89f4e2c811f49f42edf4391 |
| institution | Kabale University |
| issn | 2468-4287 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Vascular Surgery Cases and Innovative Techniques |
| spelling | doaj-art-67cbd4b5b89f4e2c811f49f42edf43912025-08-20T03:56:42ZengElsevierJournal of Vascular Surgery Cases and Innovative Techniques2468-42872025-08-0111410183710.1016/j.jvscit.2025.101837Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumabSarah Kim, BA0Patrick D. Conroy, MD1Mark Zemela, MD2Bruce L. Tjaden, Jr., MD3Cooper Medical School of Rowan University, Camden, NJDepartment of Vascular and Endovascular Surgery, Cooper University Hospital, Camden, NJ; Correspondence: Patrick D. Conroy, MD, Cooper University Hospital, 3 Cooper Plaza, Ste 411, Camden, NJ 08103Department of Vascular and Endovascular Surgery, Cooper University Hospital, Camden, NJDepartment of Vascular and Endovascular Surgery, Cooper University Hospital, Camden, NJPenetrating aortic ulcers are uncommon and life-threatening. We describe the case of a 67-year-old man who presented with fever and chills and was found on computed tomographic scan to have a thoracic penetrating aortic ulcer. The patient underwent placement of a thoracic branch endoprosthesis, with a postoperative course complicated by ileocolic pseudoaneurysm, progressive aortitis, and a fatal aortoesophageal fistula. The management of penetrating aortic ulcer in the setting of multiple confounding factors is discussed in the context of this patient’s complex medical presentation, with a focus on the potential role of pembrolizumab in his disease progression.http://www.sciencedirect.com/science/article/pii/S2468428725001194Aortoesophageal fistulaPembrolizumabPenetrating aortic ulcerThoracic branch endoprosthesis |
| spellingShingle | Sarah Kim, BA Patrick D. Conroy, MD Mark Zemela, MD Bruce L. Tjaden, Jr., MD Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab Journal of Vascular Surgery Cases and Innovative Techniques Aortoesophageal fistula Pembrolizumab Penetrating aortic ulcer Thoracic branch endoprosthesis |
| title | Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab |
| title_full | Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab |
| title_fullStr | Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab |
| title_full_unstemmed | Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab |
| title_short | Aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab |
| title_sort | aortoesophageal fistula following thoracic branch endoprosthesis for cryptogenic penetrating aortic ulcer in a patient on pembrolizumab |
| topic | Aortoesophageal fistula Pembrolizumab Penetrating aortic ulcer Thoracic branch endoprosthesis |
| url | http://www.sciencedirect.com/science/article/pii/S2468428725001194 |
| work_keys_str_mv | AT sarahkimba aortoesophagealfistulafollowingthoracicbranchendoprosthesisforcryptogenicpenetratingaorticulcerinapatientonpembrolizumab AT patrickdconroymd aortoesophagealfistulafollowingthoracicbranchendoprosthesisforcryptogenicpenetratingaorticulcerinapatientonpembrolizumab AT markzemelamd aortoesophagealfistulafollowingthoracicbranchendoprosthesisforcryptogenicpenetratingaorticulcerinapatientonpembrolizumab AT bruceltjadenjrmd aortoesophagealfistulafollowingthoracicbranchendoprosthesisforcryptogenicpenetratingaorticulcerinapatientonpembrolizumab |