Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma
Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune and epithelial cells. It plays a role...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Science Publishing & Media Ltd.
2024-10-01
|
| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024191 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525849667403776 |
|---|---|
| author | Hua Ruheng Yu Pengfei Zheng Wanting Wu Nuwa Yu Wangjianfei Kong Qingyu He Jun Qin Lei |
| author_facet | Hua Ruheng Yu Pengfei Zheng Wanting Wu Nuwa Yu Wangjianfei Kong Qingyu He Jun Qin Lei |
| author_sort | Hua Ruheng |
| collection | DOAJ |
| description | Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune and epithelial cells. It plays a role in modulating inflammatory and immune responses. In this study, we find that Tim-1 is overexpressed in hepatocellular carcinoma (HCC) samples and that its expression is significantly correlated with postoperative survival. Bulk RNA sequencing reveals a general upregulation of extracellular matrix-related genes in HCC tissues with Tim-1 overexpression. The results of the cell and in vivo experiments reveal that Tim-1 in HCC not only affects biological processes such as the proliferation, migration, and invasion of HCC cells but also broadly promotes extracellular matrix processes by influencing cytokine secretion. Further studies demonstrate that Tim-1 mediates the activation of hepatic stellate cells and upregulates Th1 and Th2 cytokines, thereby promoting HCC progression. Thus, Tim-1 may represent a novel target for future interventions in HCC and liver fibrosis. <?Pub Caret 33?> |
| format | Article |
| id | doaj-art-67ca7b2fc0724e21aeb1cad6be81df41 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-67ca7b2fc0724e21aeb1cad6be81df412025-01-17T05:58:30ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-10-01561761177310.3724/abbs.202419120d259ccTim-1-mediated extracellular matrix promotes the development of hepatocellular carcinomaHua Ruheng0Yu Pengfei1Zheng Wanting2Wu Nuwa3Yu Wangjianfei4Kong Qingyu5He Jun6Qin Lei7["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China","Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Nantong 226001, China"]["Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People’s Hospital, Wuxi 214100, China"]["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China","Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210095, China"]["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China"]["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China"]["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China"]["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China"]["Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China"]Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune and epithelial cells. It plays a role in modulating inflammatory and immune responses. In this study, we find that Tim-1 is overexpressed in hepatocellular carcinoma (HCC) samples and that its expression is significantly correlated with postoperative survival. Bulk RNA sequencing reveals a general upregulation of extracellular matrix-related genes in HCC tissues with Tim-1 overexpression. The results of the cell and in vivo experiments reveal that Tim-1 in HCC not only affects biological processes such as the proliferation, migration, and invasion of HCC cells but also broadly promotes extracellular matrix processes by influencing cytokine secretion. Further studies demonstrate that Tim-1 mediates the activation of hepatic stellate cells and upregulates Th1 and Th2 cytokines, thereby promoting HCC progression. Thus, Tim-1 may represent a novel target for future interventions in HCC and liver fibrosis. <?Pub Caret 33?>https://www.sciengine.com/doi/10.3724/abbs.2024191Tim-1extracellular matrixhepatocellular carcinomaNF-κBliver fibrosis |
| spellingShingle | Hua Ruheng Yu Pengfei Zheng Wanting Wu Nuwa Yu Wangjianfei Kong Qingyu He Jun Qin Lei Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma Acta Biochimica et Biophysica Sinica Tim-1 extracellular matrix hepatocellular carcinoma NF-κB liver fibrosis |
| title | Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma |
| title_full | Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma |
| title_fullStr | Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma |
| title_full_unstemmed | Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma |
| title_short | Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma |
| title_sort | tim 1 mediated extracellular matrix promotes the development of hepatocellular carcinoma |
| topic | Tim-1 extracellular matrix hepatocellular carcinoma NF-κB liver fibrosis |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024191 |
| work_keys_str_mv | AT huaruheng tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT yupengfei tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT zhengwanting tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT wunuwa tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT yuwangjianfei tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT kongqingyu tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT hejun tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma AT qinlei tim1mediatedextracellularmatrixpromotesthedevelopmentofhepatocellularcarcinoma |