Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis
Aim: To assess the ability of signature metabolites alone, or in combination with the model for end-stage liver disease-Na (MELD-Na) score to predict mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis. Materials & methods: Plasma metaboli...
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| Language: | English |
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Taylor & Francis Group
2020-02-01
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| Series: | Future Science OA |
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| Online Access: | https://www.future-science.com/doi/10.2144/fsoa-2019-0124 |
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| author | Ayse L Mindikoglu Cristian Coarfa Antone R Opekun Vijay H Shah Juan P Arab Konstantinos N Lazaridis Nagireddy Putluri Chandrashekar R Ambati Matthew J Robertson Sridevi Devaraj Prasun K Jalal Abbas Rana John A Goss Thomas C Dowling Matthew R Weir Stephen L Seliger Jean-Pierre Raufman David W Bernard John M Vierling |
| author_facet | Ayse L Mindikoglu Cristian Coarfa Antone R Opekun Vijay H Shah Juan P Arab Konstantinos N Lazaridis Nagireddy Putluri Chandrashekar R Ambati Matthew J Robertson Sridevi Devaraj Prasun K Jalal Abbas Rana John A Goss Thomas C Dowling Matthew R Weir Stephen L Seliger Jean-Pierre Raufman David W Bernard John M Vierling |
| author_sort | Ayse L Mindikoglu |
| collection | DOAJ |
| description | Aim: To assess the ability of signature metabolites alone, or in combination with the model for end-stage liver disease-Na (MELD-Na) score to predict mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis. Materials & methods: Plasma metabolites were detected using ultrahigh-performance liquid chromatography/tandem mass spectrometry in 39 patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis. Mortality was predicted using Cox proportional hazards regression and time-dependent receiver operating characteristic curve analyses. Results: The top five metabolites with significantly greater accuracy than the MELD-Na score (area under the receiver operating characteristic curve [AUROC] = 0.7591) to predict 1-year mortality were myo-inositol (AUROC = 0.9537), N-acetylputrescine (AUROC = 0.9018), trans-aconitate (AUROC = 0.8880), erythronate (AUROC = 0.8345) and N6-carbamoylthreonyladenosine (AUROC = 0.8055). Several combined MELD-Na-metabolite models increased the accuracy of predicted 1-year mortality substantially (AUROC increased from 0.7591 up to 0.9392). Conclusion: Plasma metabolites have the potential to enhance the accuracy of mortality predictions, minimize underestimates of mortality in patients with cirrhosis and low MELD-Na scores, and promote equitable allocation of donor livers. |
| format | Article |
| id | doaj-art-67b9ede47d7a43a09cc32b36b4d67d97 |
| institution | OA Journals |
| issn | 2056-5623 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-67b9ede47d7a43a09cc32b36b4d67d972025-08-20T02:25:48ZengTaylor & Francis GroupFuture Science OA2056-56232020-02-016210.2144/fsoa-2019-0124Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitisAyse L Mindikoglu0Cristian Coarfa1Antone R Opekun2Vijay H Shah3Juan P Arab4Konstantinos N Lazaridis5Nagireddy Putluri6Chandrashekar R Ambati7Matthew J Robertson8Sridevi Devaraj9Prasun K Jalal10Abbas Rana11John A Goss12Thomas C Dowling13Matthew R Weir14Stephen L Seliger15Jean-Pierre Raufman16David W Bernard17John M Vierling181Margaret M & Albert B Alkek Department of Medicine, Section of Gastroenterology & Hepatology, Baylor College of Medicine, Houston, TX, USA3Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, USA1Margaret M & Albert B Alkek Department of Medicine, Section of Gastroenterology & Hepatology, Baylor College of Medicine, Houston, TX, USA6Department of Medicine, Division of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA7Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile6Department of Medicine, Division of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA3Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, USA3Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, USA3Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, USA8Clinical Chemistry & Point of Care Technology, Texas Children's Hospital & Health Centers, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA1Margaret M & Albert B Alkek Department of Medicine, Section of Gastroenterology & Hepatology, Baylor College of Medicine, Houston, TX, USA2Michael E DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, USA2Michael E DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, USA9Ferris State University, College of Pharmacy, Grand Rapids, MI, USA10Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA10Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA11Department of Medicine, Division of Gastroenterology & Hepatology, University of Maryland School of Medicine, Baltimore, MD, USA12Department of Pathology & Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA1Margaret M & Albert B Alkek Department of Medicine, Section of Gastroenterology & Hepatology, Baylor College of Medicine, Houston, TX, USAAim: To assess the ability of signature metabolites alone, or in combination with the model for end-stage liver disease-Na (MELD-Na) score to predict mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis. Materials & methods: Plasma metabolites were detected using ultrahigh-performance liquid chromatography/tandem mass spectrometry in 39 patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis. Mortality was predicted using Cox proportional hazards regression and time-dependent receiver operating characteristic curve analyses. Results: The top five metabolites with significantly greater accuracy than the MELD-Na score (area under the receiver operating characteristic curve [AUROC] = 0.7591) to predict 1-year mortality were myo-inositol (AUROC = 0.9537), N-acetylputrescine (AUROC = 0.9018), trans-aconitate (AUROC = 0.8880), erythronate (AUROC = 0.8345) and N6-carbamoylthreonyladenosine (AUROC = 0.8055). Several combined MELD-Na-metabolite models increased the accuracy of predicted 1-year mortality substantially (AUROC increased from 0.7591 up to 0.9392). Conclusion: Plasma metabolites have the potential to enhance the accuracy of mortality predictions, minimize underestimates of mortality in patients with cirrhosis and low MELD-Na scores, and promote equitable allocation of donor livers.https://www.future-science.com/doi/10.2144/fsoa-2019-0124biomarkercirrhosisliver transplantationMELD-Na scoremetabolitemetabolomics |
| spellingShingle | Ayse L Mindikoglu Cristian Coarfa Antone R Opekun Vijay H Shah Juan P Arab Konstantinos N Lazaridis Nagireddy Putluri Chandrashekar R Ambati Matthew J Robertson Sridevi Devaraj Prasun K Jalal Abbas Rana John A Goss Thomas C Dowling Matthew R Weir Stephen L Seliger Jean-Pierre Raufman David W Bernard John M Vierling Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis Future Science OA biomarker cirrhosis liver transplantation MELD-Na score metabolite metabolomics |
| title | Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis |
| title_full | Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis |
| title_fullStr | Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis |
| title_full_unstemmed | Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis |
| title_short | Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis |
| title_sort | metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis |
| topic | biomarker cirrhosis liver transplantation MELD-Na score metabolite metabolomics |
| url | https://www.future-science.com/doi/10.2144/fsoa-2019-0124 |
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