Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020
Abstract Background Thyroid gland disorders are a known risk factor for atrial fibrillation and flutter (AF/AFL). Despite being a well‐established risk factor, most studies have primarily examined prevalence, comorbidities, and treatment patterns with little to no research on mortality trends for th...
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| Format: | Article |
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Wiley
2025-06-01
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| Series: | Journal of Arrhythmia |
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| Online Access: | https://doi.org/10.1002/joa3.70096 |
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| author | Shahzaib Ahmed Shoaib Ahmad Hamza Ashraf Eeman Ahmad Umar Akram Abbas H. Mallick Irfan Ullah Raheel Ahmed Chadi Alraies Gregg C. Fonarow |
| author_facet | Shahzaib Ahmed Shoaib Ahmad Hamza Ashraf Eeman Ahmad Umar Akram Abbas H. Mallick Irfan Ullah Raheel Ahmed Chadi Alraies Gregg C. Fonarow |
| author_sort | Shahzaib Ahmed |
| collection | DOAJ |
| description | Abstract Background Thyroid gland disorders are a known risk factor for atrial fibrillation and flutter (AF/AFL). Despite being a well‐established risk factor, most studies have primarily examined prevalence, comorbidities, and treatment patterns with little to no research on mortality trends for this association. Objective: We aimed to analyze the trends in AF/AFL‐related mortality in patients with thyroid gland disorders. Methods Age‐adjusted mortality rates and crude rates per 100,000 population from 1999 to 2020 using the CDC WONDER database. Annual percent changes and their averages were calculated via Joinpoint regression. AF/AFL‐related mortality trends in patients with thyroid disorders were compared with those in the general population using pairwise comparison. Results In the study period, a total of 7187 AF/AFL‐related deaths were observed in individuals diagnosed with thyroid gland disorders. The age‐adjusted mortality rates increased throughout the study period. The mortality rates in females remained consistently higher than those in males. Mortality rates did not vary substantially across regions (South: 0.09; Northeast: 0.09; Midwest: 0.10; West: 0.11). Furthermore, the annual percent change in females and South with thyroid disorders differed significantly from the general population. The states with the highest mortality rates were Oregon, Wyoming, and Nebraska. The mortality rates remained higher in nonmetropolitan regions (0.11) than in metropolitan regions (0.09). Conclusions AF/AFL‐related mortality trends associated with thyroid disorders increased from 1999 to 2020. Policies that target vulnerable populations and regions may be beneficial in mitigating the increasing AF/AFL‐related mortality associated with disorders of the thyroid gland. |
| format | Article |
| id | doaj-art-67b9d0eb2f2d41a8aedacbe83e3cd405 |
| institution | Kabale University |
| issn | 1880-4276 1883-2148 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj-art-67b9d0eb2f2d41a8aedacbe83e3cd4052025-08-20T03:27:11ZengWileyJournal of Arrhythmia1880-42761883-21482025-06-01413n/an/a10.1002/joa3.70096Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020Shahzaib Ahmed0Shoaib Ahmad1Hamza Ashraf2Eeman Ahmad3Umar Akram4Abbas H. Mallick5Irfan Ullah6Raheel Ahmed7Chadi Alraies8Gregg C. Fonarow9Department of Medicine Fatima Memorial Hospital College of Medicine and Dentistry Lahore PakistanSt. Joseph Hospital and Medical Center Phoenix Arizona USADepartment of Medicine Allama Iqbal Medical College Lahore PakistanDepartment of Medicine Fatima Memorial Hospital College of Medicine and Dentistry Lahore PakistanDepartment of Medicine Allama Iqbal Medical College Lahore PakistanDepartment of Internal Medicine The Brooklyn Hospital Center Brooklyn New York USADepartment of Internal Medicine Khyber Teaching Hospital Peshawar PakistanNational Heart and Lung Institute Imperial College London London UKDepartment of Cardiology Detroit Medical Center Detroit Michigan USADivision of Cardiology University of California Los Angeles California USAAbstract Background Thyroid gland disorders are a known risk factor for atrial fibrillation and flutter (AF/AFL). Despite being a well‐established risk factor, most studies have primarily examined prevalence, comorbidities, and treatment patterns with little to no research on mortality trends for this association. Objective: We aimed to analyze the trends in AF/AFL‐related mortality in patients with thyroid gland disorders. Methods Age‐adjusted mortality rates and crude rates per 100,000 population from 1999 to 2020 using the CDC WONDER database. Annual percent changes and their averages were calculated via Joinpoint regression. AF/AFL‐related mortality trends in patients with thyroid disorders were compared with those in the general population using pairwise comparison. Results In the study period, a total of 7187 AF/AFL‐related deaths were observed in individuals diagnosed with thyroid gland disorders. The age‐adjusted mortality rates increased throughout the study period. The mortality rates in females remained consistently higher than those in males. Mortality rates did not vary substantially across regions (South: 0.09; Northeast: 0.09; Midwest: 0.10; West: 0.11). Furthermore, the annual percent change in females and South with thyroid disorders differed significantly from the general population. The states with the highest mortality rates were Oregon, Wyoming, and Nebraska. The mortality rates remained higher in nonmetropolitan regions (0.11) than in metropolitan regions (0.09). Conclusions AF/AFL‐related mortality trends associated with thyroid disorders increased from 1999 to 2020. Policies that target vulnerable populations and regions may be beneficial in mitigating the increasing AF/AFL‐related mortality associated with disorders of the thyroid gland.https://doi.org/10.1002/joa3.70096atrial fibrillationatrial flutterdisorders of thyroid glandmortality |
| spellingShingle | Shahzaib Ahmed Shoaib Ahmad Hamza Ashraf Eeman Ahmad Umar Akram Abbas H. Mallick Irfan Ullah Raheel Ahmed Chadi Alraies Gregg C. Fonarow Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020 Journal of Arrhythmia atrial fibrillation atrial flutter disorders of thyroid gland mortality |
| title | Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020 |
| title_full | Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020 |
| title_fullStr | Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020 |
| title_full_unstemmed | Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020 |
| title_short | Trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the United States from 1999 to 2020 |
| title_sort | trends in atrial fibrillation and flutter mortality associated with disorders of thyroid gland in the united states from 1999 to 2020 |
| topic | atrial fibrillation atrial flutter disorders of thyroid gland mortality |
| url | https://doi.org/10.1002/joa3.70096 |
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