A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures
Objective: to investigate the effectiveness of diluted antibiotic hydrogels in endodontic regeneration procedures. Materials and Methods: One conventional treatment (calcium hydroxide) and two experimental treatments containing 1 mg/mL antibiotic in gel (MC-TAP and MC-DAP) were prepared for this stu...
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| Format: | Article |
| Language: | English |
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Springer
2023-11-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223001177 |
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| author | Alaa H.A Sabrah Mohammad M. Hammad Fouad K Wahab Abeer AlHadidi Nesreen A Salim Ayman F. Alelaimat Ibrahim Khatib |
| author_facet | Alaa H.A Sabrah Mohammad M. Hammad Fouad K Wahab Abeer AlHadidi Nesreen A Salim Ayman F. Alelaimat Ibrahim Khatib |
| author_sort | Alaa H.A Sabrah |
| collection | DOAJ |
| description | Objective: to investigate the effectiveness of diluted antibiotic hydrogels in endodontic regeneration procedures. Materials and Methods: One conventional treatment (calcium hydroxide) and two experimental treatments containing 1 mg/mL antibiotic in gel (MC-TAP and MC-DAP) were prepared for this study. The effect of these medicaments on the proliferation and differentiation potential of dental pulp stem cells (DPSCs) was examined before their clinical use, using WST and ALP assays. Twenty-two teeth diagnosed with necrotic immature roots were treated with calcium hydroxide, MC-TAP or MC-DAP using the endodontic regeneration protocol as described by the American Association of Endodontists (AAE). Teeth were examined after application of the medicament, at the time of regeneration and after 12–24 months. Results: All treated teeth showed resolution of signs and symptoms shortly after treatment with the different medicaments. However, signs and symptoms returned a few months after initial treatment in clinical cases treated with MC-DAP. All successfully treated teeth examined after 12–24 months were free of signs and symptoms, but vitality was not achieved. Conclusion: Low concentration antibiotic gel containing triple antibiotic paste (MC-TAP) can be successfully used for endodontic regeneration procedures. |
| format | Article |
| id | doaj-art-67b87ab5d61b4a058b0ae46a32fc36f6 |
| institution | Kabale University |
| issn | 1013-9052 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-67b87ab5d61b4a058b0ae46a32fc36f62025-08-20T03:33:50ZengSpringerSaudi Dental Journal1013-90522023-11-0135785486010.1016/j.sdentj.2023.06.005A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration proceduresAlaa H.A Sabrah0Mohammad M. Hammad1Fouad K Wahab2Abeer AlHadidi3Nesreen A Salim4Ayman F. Alelaimat5Ibrahim Khatib6The University of Jordan, Department of Restorative dentistry, Amman 11942, Jordan; Corresponding author at: Department of Restorative Dentistry, The University of Jordan, Queen Rania Al-Abdallah Street, Amman 11942, Jordan.The University of Jordan, Department of Restorative dentistry, Amman 11942, JordanThe University of Jordan, Department of Restorative dentistry, Amman 11942, JordanThe University of Jordan, Department of maxillofacial surgery, Amman 11942, JordanThe University of Jordan, Department of Removable prosthodontics, Amman 11942, JordanJordanian Royal Medical Services, Amman, JordanThe University of Jordan, Department of Removable prosthodontics, Amman 11942, JordanObjective: to investigate the effectiveness of diluted antibiotic hydrogels in endodontic regeneration procedures. Materials and Methods: One conventional treatment (calcium hydroxide) and two experimental treatments containing 1 mg/mL antibiotic in gel (MC-TAP and MC-DAP) were prepared for this study. The effect of these medicaments on the proliferation and differentiation potential of dental pulp stem cells (DPSCs) was examined before their clinical use, using WST and ALP assays. Twenty-two teeth diagnosed with necrotic immature roots were treated with calcium hydroxide, MC-TAP or MC-DAP using the endodontic regeneration protocol as described by the American Association of Endodontists (AAE). Teeth were examined after application of the medicament, at the time of regeneration and after 12–24 months. Results: All treated teeth showed resolution of signs and symptoms shortly after treatment with the different medicaments. However, signs and symptoms returned a few months after initial treatment in clinical cases treated with MC-DAP. All successfully treated teeth examined after 12–24 months were free of signs and symptoms, but vitality was not achieved. Conclusion: Low concentration antibiotic gel containing triple antibiotic paste (MC-TAP) can be successfully used for endodontic regeneration procedures.http://www.sciencedirect.com/science/article/pii/S1013905223001177Triple Antibiotic HydrogelsDouble Antibiotic HydrogelsRegenerative EndodonticsNecrotic Teeth |
| spellingShingle | Alaa H.A Sabrah Mohammad M. Hammad Fouad K Wahab Abeer AlHadidi Nesreen A Salim Ayman F. Alelaimat Ibrahim Khatib A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures Saudi Dental Journal Triple Antibiotic Hydrogels Double Antibiotic Hydrogels Regenerative Endodontics Necrotic Teeth |
| title | A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures |
| title_full | A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures |
| title_fullStr | A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures |
| title_full_unstemmed | A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures |
| title_short | A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures |
| title_sort | prospective case series in regenerative endodontics the effective use of diluted antibiotic hydrogels in endodontic regeneration procedures |
| topic | Triple Antibiotic Hydrogels Double Antibiotic Hydrogels Regenerative Endodontics Necrotic Teeth |
| url | http://www.sciencedirect.com/science/article/pii/S1013905223001177 |
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