Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis

Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis

Alveolar echinococcosis (AE) is a severe zoonotic disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis. We recently showed that E. multilocularis metacestode vesicles scavenge large amounts of L-threonine from the culture medium. This motivated us to study the effe...

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Bibliographic Details
Main Authors: Marc Kaethner, Pascal Zumstein, Joachim Müller, Matías Preza, Philipp Grossenbacher, Anissa Bartetzko, Laura Vetter, Martin Lochner, Stefan Schürch, Clement Regnault, Daniel Villalobos Ramírez, Britta Lundström-Stadelmann
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Echinococcus multilocularis
Cestode
Threonine metabolism
Target-based screening
Disulfiram
Sanguinarine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320725000041
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