Clinical risk factors for sarcopenia in acute and chronic pancreatitis
Abstract Background Sarcopenia is common in chronic pancreatitis (CP) and has been associated with unfavorable outcomes; however, it is not well studied in acute pancreatitis (AP). Aims To evaluate risk factors for sarcopenia among individuals with AP or CP. Methods A cross sectional analysis was pe...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03609-4 |
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| author | Mitchell L. Ramsey Andrew Lu Kristyn Gumpper-Fedus Stacey Culp David Bradley Darwin L. Conwell Zobeida Cruz-Monserrate J. Royce Groce Samuel Han Somashekar G. Krishna Peter Lee Thomas Mace Georgios I. Papachristou Kristen M. Roberts Zarine K. Shah Phil A. Hart |
| author_facet | Mitchell L. Ramsey Andrew Lu Kristyn Gumpper-Fedus Stacey Culp David Bradley Darwin L. Conwell Zobeida Cruz-Monserrate J. Royce Groce Samuel Han Somashekar G. Krishna Peter Lee Thomas Mace Georgios I. Papachristou Kristen M. Roberts Zarine K. Shah Phil A. Hart |
| author_sort | Mitchell L. Ramsey |
| collection | DOAJ |
| description | Abstract Background Sarcopenia is common in chronic pancreatitis (CP) and has been associated with unfavorable outcomes; however, it is not well studied in acute pancreatitis (AP). Aims To evaluate risk factors for sarcopenia among individuals with AP or CP. Methods A cross sectional analysis was performed among subjects with AP or CP seen in a tertiary care Pancreas Clinic. TeraRecon software was used to calculate the cross-sectional area of skeletal muscle, visceral fat, and subcutaneous fat at the level of the L3 vertebrae. Sarcopenia was classified using sex-specific skeletal muscle index. Univariate and multivariate logistic regressions were performed to assess differences between groups and associations with sarcopenia. Results A total of 49 subjects with AP and 54 subjects with CP were included. Sarcopenia was more frequently observed in CP compared to AP (83.3% vs. 46.9%, p < 0.001). The multivariate logistic regression demonstrated CP, male sex, increased age, and decreased subcutaneous fat were independently associated with sarcopenia. Conclusion Sarcopenia is observed in both CP and AP. In addition to traditional risk factors (including male sex, older age, and decreased subcutaneous fat), CP is independently associated with sarcopenia. Further investigations are necessary to gain deeper insights into sarcopenia pathogenesis, which could inform potential intervention strategies. |
| format | Article |
| id | doaj-art-67b497654bbe4b7185e2ef9c2428a7fd |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-67b497654bbe4b7185e2ef9c2428a7fd2025-02-09T12:39:36ZengBMCBMC Gastroenterology1471-230X2025-02-012511910.1186/s12876-025-03609-4Clinical risk factors for sarcopenia in acute and chronic pancreatitisMitchell L. Ramsey0Andrew Lu1Kristyn Gumpper-Fedus2Stacey Culp3David Bradley4Darwin L. Conwell5Zobeida Cruz-Monserrate6J. Royce Groce7Samuel Han8Somashekar G. Krishna9Peter Lee10Thomas Mace11Georgios I. Papachristou12Kristen M. Roberts13Zarine K. Shah14Phil A. Hart15Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDepartment of Radiology, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDepartment of Biomedical Informatics, The Ohio State University College of MedicineDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Penn State Health Milton S. Hershey Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterDepartment of Radiology, The Ohio State University Wexner Medical CenterDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical CenterAbstract Background Sarcopenia is common in chronic pancreatitis (CP) and has been associated with unfavorable outcomes; however, it is not well studied in acute pancreatitis (AP). Aims To evaluate risk factors for sarcopenia among individuals with AP or CP. Methods A cross sectional analysis was performed among subjects with AP or CP seen in a tertiary care Pancreas Clinic. TeraRecon software was used to calculate the cross-sectional area of skeletal muscle, visceral fat, and subcutaneous fat at the level of the L3 vertebrae. Sarcopenia was classified using sex-specific skeletal muscle index. Univariate and multivariate logistic regressions were performed to assess differences between groups and associations with sarcopenia. Results A total of 49 subjects with AP and 54 subjects with CP were included. Sarcopenia was more frequently observed in CP compared to AP (83.3% vs. 46.9%, p < 0.001). The multivariate logistic regression demonstrated CP, male sex, increased age, and decreased subcutaneous fat were independently associated with sarcopenia. Conclusion Sarcopenia is observed in both CP and AP. In addition to traditional risk factors (including male sex, older age, and decreased subcutaneous fat), CP is independently associated with sarcopenia. Further investigations are necessary to gain deeper insights into sarcopenia pathogenesis, which could inform potential intervention strategies.https://doi.org/10.1186/s12876-025-03609-4SarcopeniaSubcutaneous fatVisceral fatSkeletal muscleBody composition |
| spellingShingle | Mitchell L. Ramsey Andrew Lu Kristyn Gumpper-Fedus Stacey Culp David Bradley Darwin L. Conwell Zobeida Cruz-Monserrate J. Royce Groce Samuel Han Somashekar G. Krishna Peter Lee Thomas Mace Georgios I. Papachristou Kristen M. Roberts Zarine K. Shah Phil A. Hart Clinical risk factors for sarcopenia in acute and chronic pancreatitis BMC Gastroenterology Sarcopenia Subcutaneous fat Visceral fat Skeletal muscle Body composition |
| title | Clinical risk factors for sarcopenia in acute and chronic pancreatitis |
| title_full | Clinical risk factors for sarcopenia in acute and chronic pancreatitis |
| title_fullStr | Clinical risk factors for sarcopenia in acute and chronic pancreatitis |
| title_full_unstemmed | Clinical risk factors for sarcopenia in acute and chronic pancreatitis |
| title_short | Clinical risk factors for sarcopenia in acute and chronic pancreatitis |
| title_sort | clinical risk factors for sarcopenia in acute and chronic pancreatitis |
| topic | Sarcopenia Subcutaneous fat Visceral fat Skeletal muscle Body composition |
| url | https://doi.org/10.1186/s12876-025-03609-4 |
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