Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective
Objective: To investigate the influence of cannabis consumption on the mid- and long-term surgical outcomes of patients with aortic aneurysms or dissections. Methods: All individuals aged 18 years and older with more than 6 months of cannabis use at the time of surgical repair for cardiovascular dis...
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Elsevier
2024-12-01
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| Series: | JTCVS Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666273624002237 |
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| author | Lucas Ribé Bernal, MD Akiko Tanaka, MD, PhD Yuki Ikeno, MD Rana O. Afifi, MD Harleen K. Sandhu, MD, MPH Charles C. Miller, III, PhD Anthony L. Estrera, MD |
| author_facet | Lucas Ribé Bernal, MD Akiko Tanaka, MD, PhD Yuki Ikeno, MD Rana O. Afifi, MD Harleen K. Sandhu, MD, MPH Charles C. Miller, III, PhD Anthony L. Estrera, MD |
| author_sort | Lucas Ribé Bernal, MD |
| collection | DOAJ |
| description | Objective: To investigate the influence of cannabis consumption on the mid- and long-term surgical outcomes of patients with aortic aneurysms or dissections. Methods: All individuals aged 18 years and older with more than 6 months of cannabis use at the time of surgical repair for cardiovascular disease (aortic aneurysms or aortic dissection) between 2007 and 2023 were eligible. Patients were stratified into 2 groups based on their preoperative history of cannabis use: cannabis users and noncannabis users. The primary end point was complications or death within 30 days of intervention. Secondary outcomes included late complications and reinterventions. Data were combined from our institution and inpatient hospital records. Results: We identified 134 patients who met the inclusion criteria out of 1543 treated patients (9%). Compared with the nonusing cannabis group, individuals in the cannabis group were significantly younger (cannabis: 48.3 ± 11.8 years vs noncannabis: 58.5 ± 14.9 years; P < .001). The cannabis group included significantly higher patients with Marfan syndrome (cannabis: 11.2% vs noncannabis: 4.4%; P < .001). Furthermore, the cannabis group showed significantly higher history of recreational drug use, including cocaine (25.4% vs 1.6%; P < .001), amphetamines (3.7% vs 0.6%; P < .001), opioids (8.2% vs 0.5%; P < .001), and intravenous drugs (6.7% vs 0.6%; P < .001). Emergency surgeries were significantly more frequent in the cannabis group (cannabis: 56.7% vs noncannabis: 36.2%; P < .001). Surgical mortality was comparable between both groups (cannabis: 9.7% vs noncannabis: 8.6%; P = .662). Postoperative stroke was significantly higher in the cannabis group (cannabis: 14.9% vs noncannabis: 8.2%; P = .009), and the rate of postoperative respiratory complications was also significantly higher in the cannabis group (cannabis: 32.1% vs noncannabis: 19.0%; P < .001). Conclusions: The increased rates of postoperative cerebrovascular accidents and respiratory complications suggest that cannabis use is a significant risk factor in aortic surgery. Our study showed that young, healthy patients with prolonged cannabis use might be at a higher risk of requiring more emergency surgeries due to their background. |
| format | Article |
| id | doaj-art-67b4918c0ff040b99823fc4d2b2e35cd |
| institution | OA Journals |
| issn | 2666-2736 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| spelling | doaj-art-67b4918c0ff040b99823fc4d2b2e35cd2025-08-20T02:38:05ZengElsevierJTCVS Open2666-27362024-12-012210711310.1016/j.xjon.2024.08.002Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspectiveLucas Ribé Bernal, MD0Akiko Tanaka, MD, PhD1Yuki Ikeno, MD2Rana O. Afifi, MD3Harleen K. Sandhu, MD, MPH4Charles C. Miller, III, PhD5Anthony L. Estrera, MD6Address for reprints: Lucas Ribé Bernal, MD, Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, 6400 Fannin St, Suite 2850, Houston, TX 77030.; Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at UTHealth Houston, Houston, TexObjective: To investigate the influence of cannabis consumption on the mid- and long-term surgical outcomes of patients with aortic aneurysms or dissections. Methods: All individuals aged 18 years and older with more than 6 months of cannabis use at the time of surgical repair for cardiovascular disease (aortic aneurysms or aortic dissection) between 2007 and 2023 were eligible. Patients were stratified into 2 groups based on their preoperative history of cannabis use: cannabis users and noncannabis users. The primary end point was complications or death within 30 days of intervention. Secondary outcomes included late complications and reinterventions. Data were combined from our institution and inpatient hospital records. Results: We identified 134 patients who met the inclusion criteria out of 1543 treated patients (9%). Compared with the nonusing cannabis group, individuals in the cannabis group were significantly younger (cannabis: 48.3 ± 11.8 years vs noncannabis: 58.5 ± 14.9 years; P < .001). The cannabis group included significantly higher patients with Marfan syndrome (cannabis: 11.2% vs noncannabis: 4.4%; P < .001). Furthermore, the cannabis group showed significantly higher history of recreational drug use, including cocaine (25.4% vs 1.6%; P < .001), amphetamines (3.7% vs 0.6%; P < .001), opioids (8.2% vs 0.5%; P < .001), and intravenous drugs (6.7% vs 0.6%; P < .001). Emergency surgeries were significantly more frequent in the cannabis group (cannabis: 56.7% vs noncannabis: 36.2%; P < .001). Surgical mortality was comparable between both groups (cannabis: 9.7% vs noncannabis: 8.6%; P = .662). Postoperative stroke was significantly higher in the cannabis group (cannabis: 14.9% vs noncannabis: 8.2%; P = .009), and the rate of postoperative respiratory complications was also significantly higher in the cannabis group (cannabis: 32.1% vs noncannabis: 19.0%; P < .001). Conclusions: The increased rates of postoperative cerebrovascular accidents and respiratory complications suggest that cannabis use is a significant risk factor in aortic surgery. Our study showed that young, healthy patients with prolonged cannabis use might be at a higher risk of requiring more emergency surgeries due to their background.http://www.sciencedirect.com/science/article/pii/S2666273624002237aneurysmaortic repaircannabis usedissection |
| spellingShingle | Lucas Ribé Bernal, MD Akiko Tanaka, MD, PhD Yuki Ikeno, MD Rana O. Afifi, MD Harleen K. Sandhu, MD, MPH Charles C. Miller, III, PhD Anthony L. Estrera, MD Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective JTCVS Open aneurysm aortic repair cannabis use dissection |
| title | Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective |
| title_full | Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective |
| title_fullStr | Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective |
| title_full_unstemmed | Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective |
| title_short | Outcomes after open repair of aortic aneurysms and dissections in cannabis consumersCentral MessagePerspective |
| title_sort | outcomes after open repair of aortic aneurysms and dissections in cannabis consumerscentral messageperspective |
| topic | aneurysm aortic repair cannabis use dissection |
| url | http://www.sciencedirect.com/science/article/pii/S2666273624002237 |
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