Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure
ABSTRACT: Background: Strain analysis offers a valuable tool to assess myocardial mechanics, allowing for the detection of impairments in heart function. This study aims to evaluate the pattern of myocardial strain in patients with heart failure (HF). Methods: In the present study, myocardial strai...
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Elsevier
2024-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724011384 |
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| author | Yufan Gao Boxin Li Yanhe Ma Shuo Liang Anhong Yu Hong Zhang Zhigang Guo |
| author_facet | Yufan Gao Boxin Li Yanhe Ma Shuo Liang Anhong Yu Hong Zhang Zhigang Guo |
| author_sort | Yufan Gao |
| collection | DOAJ |
| description | ABSTRACT: Background: Strain analysis offers a valuable tool to assess myocardial mechanics, allowing for the detection of impairments in heart function. This study aims to evaluate the pattern of myocardial strain in patients with heart failure (HF). Methods: In the present study, myocardial strain was measured by cardiac magnetic resonance imaging feature tracking in 35 control subjects without HF and 195 HF patients. The HF patients were further categorized as HF with preserved ejection fraction (HFpEF, n = 80), with mid-range ejection fraction (HFmrEF, n = 34), and with reduced ejection fraction (HFrEF, n = 81). Additionally, quantitative tissue evaluation parameters, including native T1 relaxation time and extracellular volume (ECV), were examined. Results: Compared to controls, patients in all HF groups (HFpEF, HFmrEF, and HFrEF) demonstrated impaired left ventricular (LV) strains and systolic and diastolic strain rates in all three directions (radial, circumferential, and longitudinal) (p < 0.05 for all). LV strains also showed significant correlations with LV ejection fraction and brain natriuretic peptide levels (p < 0.001 for all). Notably, septal contraction was significantly affected in HFpEF compared to controls. While LV torsion was slightly increased in HFpEF, it was decreased in HFrEF. Native T1 relaxation times and ECV fractions were significantly higher in HFrEF compared to HFpEF (p < 0.05). Overall, myocardial strain parameters demonstrated good performance in differentiating HF categories. Conclusions: The myocardial strain impairments exhibit a spectrum of severity in patients with HFpEF, HFmrEF, and HFrEF compared to controls. Assessment of myocardial mechanics using strain analysis may offer a clinically useful tool for monitoring the progression of systolic and diastolic dysfunction in HF patients. |
| format | Article |
| id | doaj-art-67abc9ec2e9348c1855073d5abe8b88a |
| institution | OA Journals |
| issn | 1097-6647 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-67abc9ec2e9348c1855073d5abe8b88a2025-08-20T01:56:48ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472024-01-0126210111110.1016/j.jocmr.2024.101111Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failureYufan Gao0Boxin Li1Yanhe Ma2Shuo Liang3Anhong Yu4Hong Zhang5Zhigang Guo6Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China; Department of Radiology, Chest Hospital, Tianjin University, Tianjin 300222, ChinaDepartment of Radiology, Chest Hospital, Tianjin University, Tianjin 300222, ChinaDepartment of Radiology, Chest Hospital, Tianjin University, Tianjin 300222, ChinaDepartment of Radiology, Chest Hospital, Tianjin University, Tianjin 300222, ChinaDepartment of Radiology, Chest Hospital, Tianjin University, Tianjin 300222, ChinaDepartment of Radiology, Chest Hospital, Tianjin University, Tianjin 300222, China; Correspondence to: Department of Radiology, Chest Hospital, Tianjin University, No. 261 Taierzhuang South Road, Jinnan District, Tianjin 300222, China.Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin 300222, China; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin 300222, China; Correspondence to: Department of Cardiac Surgery, Chest Hospital, Tianjin University, No. 261 Taierzhuang South Road, Jinnan District, Tianjin 300222, China.ABSTRACT: Background: Strain analysis offers a valuable tool to assess myocardial mechanics, allowing for the detection of impairments in heart function. This study aims to evaluate the pattern of myocardial strain in patients with heart failure (HF). Methods: In the present study, myocardial strain was measured by cardiac magnetic resonance imaging feature tracking in 35 control subjects without HF and 195 HF patients. The HF patients were further categorized as HF with preserved ejection fraction (HFpEF, n = 80), with mid-range ejection fraction (HFmrEF, n = 34), and with reduced ejection fraction (HFrEF, n = 81). Additionally, quantitative tissue evaluation parameters, including native T1 relaxation time and extracellular volume (ECV), were examined. Results: Compared to controls, patients in all HF groups (HFpEF, HFmrEF, and HFrEF) demonstrated impaired left ventricular (LV) strains and systolic and diastolic strain rates in all three directions (radial, circumferential, and longitudinal) (p < 0.05 for all). LV strains also showed significant correlations with LV ejection fraction and brain natriuretic peptide levels (p < 0.001 for all). Notably, septal contraction was significantly affected in HFpEF compared to controls. While LV torsion was slightly increased in HFpEF, it was decreased in HFrEF. Native T1 relaxation times and ECV fractions were significantly higher in HFrEF compared to HFpEF (p < 0.05). Overall, myocardial strain parameters demonstrated good performance in differentiating HF categories. Conclusions: The myocardial strain impairments exhibit a spectrum of severity in patients with HFpEF, HFmrEF, and HFrEF compared to controls. Assessment of myocardial mechanics using strain analysis may offer a clinically useful tool for monitoring the progression of systolic and diastolic dysfunction in HF patients.http://www.sciencedirect.com/science/article/pii/S1097664724011384Heart failureMyocardial mechanicsCMRStrain |
| spellingShingle | Yufan Gao Boxin Li Yanhe Ma Shuo Liang Anhong Yu Hong Zhang Zhigang Guo Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure Journal of Cardiovascular Magnetic Resonance Heart failure Myocardial mechanics CMR Strain |
| title | Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure |
| title_full | Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure |
| title_fullStr | Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure |
| title_full_unstemmed | Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure |
| title_short | Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure |
| title_sort | myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure |
| topic | Heart failure Myocardial mechanics CMR Strain |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724011384 |
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