Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association
The aim of publication. To present modern concept on etiology and pathogenesis of the peptic ulcer (PUD) to general practitioners, to acquaint them with modern diagnostic methods and main treatment approaches of this disease. Summary. The PUD continues to remain one of the most widespread digestive...
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/95 |
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| author | V. T. Ivashkin A. A. Sheptulin I. V. Mayev Ye. K. Baranskaya A. S. Trukhmanov T. L. Lapina S. G. Burkov A. V. Kalinin A. V. Tkachev |
| author_facet | V. T. Ivashkin A. A. Sheptulin I. V. Mayev Ye. K. Baranskaya A. S. Trukhmanov T. L. Lapina S. G. Burkov A. V. Kalinin A. V. Tkachev |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | The aim of publication. To present modern concept on etiology and pathogenesis of the peptic ulcer (PUD) to general practitioners, to acquaint them with modern diagnostic methods and main treatment approaches of this disease. Summary. The PUD continues to remain one of the most widespread digestive disease. Despite a tendency to decrease of hospital admission rate of patients with uncomplicated PUD, increase in complicated forms of disease rate is noted that it is related mainly to the growing intake of non-steroidal anti-inflammatory drugs (NSAID). Helicobacter pylori infection has a leading role as PUD ethological factor. None H. pylori-associated gastroduodenal ulcers may be caused by NSAID intake or may develop within the other nosological entities (symptomatic stomach and duodenal ulcers). PUD diagnosis includes obligatory testing for H. pylori infection and carrying out eradication in the case of positive takes. At the present time the first line of antihelicobacter therapy includes standard triple clarithromycin and amoxicillin-based therapy, as well as quadrotherapy with bismuth drugs. The second line eradication therapy includes quadrotherapy with bismuth drugs and triple levofloxacin-based therapy. The third line therapy modes should be chosen after assessment of individual antibiotic sensitivity of H. pylori strains. The efficacy control of antihelicobacter treatment should be carried out not earlier than 4 weeks after the end of eradication. Conclusion. Strict conformance of diagnostic algorithm for this category of patients as well as the eradication therapy protocol allows to decrease considerably the risk of recurrence of PUD and its complications. |
| format | Article |
| id | doaj-art-67a6b822db5a4f348b3c70302bf3a1b0 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-67a6b822db5a4f348b3c70302bf3a1b02025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01266405410.22416/1382-4376-2016-6-40-5495Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological AssociationV. T. Ivashkin0A. A. Sheptulin1I. V. Mayev2Ye. K. Baranskaya3A. S. Trukhmanov4T. L. Lapina5S. G. Burkov6A. V. Kalinin7A. V. Tkachev8Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Federal state educational government-financed institution of higher education «Yevdokimov Moscow State University of Medicine and Dentistry»Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»State government-financed healthcare institution «Policlinic No. 3 of general affairs department of the President of the Russian Federation»State government-financed healthcare institution «Vladimirsky Moscow regional research clinical institute»Federal state government-financed institution of higher education «The Rostov state medical university»The aim of publication. To present modern concept on etiology and pathogenesis of the peptic ulcer (PUD) to general practitioners, to acquaint them with modern diagnostic methods and main treatment approaches of this disease. Summary. The PUD continues to remain one of the most widespread digestive disease. Despite a tendency to decrease of hospital admission rate of patients with uncomplicated PUD, increase in complicated forms of disease rate is noted that it is related mainly to the growing intake of non-steroidal anti-inflammatory drugs (NSAID). Helicobacter pylori infection has a leading role as PUD ethological factor. None H. pylori-associated gastroduodenal ulcers may be caused by NSAID intake or may develop within the other nosological entities (symptomatic stomach and duodenal ulcers). PUD diagnosis includes obligatory testing for H. pylori infection and carrying out eradication in the case of positive takes. At the present time the first line of antihelicobacter therapy includes standard triple clarithromycin and amoxicillin-based therapy, as well as quadrotherapy with bismuth drugs. The second line eradication therapy includes quadrotherapy with bismuth drugs and triple levofloxacin-based therapy. The third line therapy modes should be chosen after assessment of individual antibiotic sensitivity of H. pylori strains. The efficacy control of antihelicobacter treatment should be carried out not earlier than 4 weeks after the end of eradication. Conclusion. Strict conformance of diagnostic algorithm for this category of patients as well as the eradication therapy protocol allows to decrease considerably the risk of recurrence of PUD and its complications.https://www.gastro-j.ru/jour/article/view/95язва желудкаязва двенадцатиперстной кишкиинфекция helicobacter pyloriэрадикацияингибиторы протонной помпы |
| spellingShingle | V. T. Ivashkin A. A. Sheptulin I. V. Mayev Ye. K. Baranskaya A. S. Trukhmanov T. L. Lapina S. G. Burkov A. V. Kalinin A. V. Tkachev Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association Российский журнал гастроэнтерологии, гепатологии, колопроктологии язва желудка язва двенадцатиперстной кишки инфекция helicobacter pylori эрадикация ингибиторы протонной помпы |
| title | Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association |
| title_full | Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association |
| title_fullStr | Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association |
| title_full_unstemmed | Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association |
| title_short | Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association |
| title_sort | diagnostics and treatment of peptic ulcer clinical guidelines of the russian gastroenterological association |
| topic | язва желудка язва двенадцатиперстной кишки инфекция helicobacter pylori эрадикация ингибиторы протонной помпы |
| url | https://www.gastro-j.ru/jour/article/view/95 |
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