Synthesis of Triazolyl Derivatives Based on Thiazolo[3,2-<i>a</i>]pyrimidine Propargyl Ethers

Synthesis of Triazolyl Derivatives Based on Thiazolo[3,2-<i>a</i>]pyrimidine Propargyl Ethers

This work is devoted to the synthesis of triazolyl derivatives based on propargyl ethers of the thiazolo[3,2-<i>a</i>]pyrimidine series by [3+2]-cycloaddition and the study of their structure in solution and crystalline phase. The formation of homochiral chains in the crystalline phase i...

Full description

Saved in:
Bibliographic Details
Main Authors: Elina Gabitova, Artem Agarkov, Mariya Mailyan, Anna Nefedova, Alexander Ovsyannikov, Lubov Frantsuzova, Olga Lodochnikova, Svetlana Solovieva, Igor Antipin
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Chemistry Proceedings
Subjects:
thiazolo[3,2-<i>a</i>]pyrimidine
triazole
[3+2]-cycloaddition
propargyl ether
crystalline phase
non-covalent interactions
Online Access:https://www.mdpi.com/2673-4583/16/1/43
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This work is devoted to the synthesis of triazolyl derivatives based on propargyl ethers of the thiazolo[3,2-<i>a</i>]pyrimidine series by [3+2]-cycloaddition and the study of their structure in solution and crystalline phase. The formation of homochiral chains in the crystalline phase is attributed to the establishment of a halogen bond between the bromine atom and the nitrogen atom of the nitrile group. Additionally, the generation of a racemic dimer is linked to the formation of a halogen bond between the bromine atom and the nitrogen atom of the triazolyl fragment.
ISSN:2673-4583

Similar Items