LSD1 is a targetable vulnerability in gastric cancer harboring TP53 frameshift mutations

Abstract Background TP53 mutations are linked to aggressive progression and chemoresistance in gastric cancer (GC). Frameshift mutation is the second most common mutation type of TP53. However, the consequences of this mutation type in GC were not well understood, and targeted therapies for cancer p...

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Main Authors: Suzeng Wang, Chunyu Yang, Junhui Tang, Kaiqing Wang, Hao Cheng, Surui Yao, Zhaohui Huang, Bojian Fei
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Clinical Epigenetics
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Online Access:https://doi.org/10.1186/s13148-025-01829-9
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