Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1
The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and de...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/73835 |
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| author | Eric F. Morand Pam Hall Paul Hutchinson Yuan H. Yang |
| author_facet | Eric F. Morand Pam Hall Paul Hutchinson Yuan H. Yang |
| author_sort | Eric F. Morand |
| collection | DOAJ |
| description | The glucocorticoid (GC)-induced antiinflammatory
molecule annexin I is expressed in leukocytes and has
antiinflammatory effects in animal models of arthritis, but the
expression of annexin I in rheumatoid arthritis (RA)
fibroblast-like synoviocytes (FLS) is unknown. We report the
constitutive and dexamethasone (DEX)-inducible expression of
annexin I in RA FLS. DEX increased FLS annexin I protein
translocation and mRNA expression. Interleukin (IL)-1β also induced annexin I translocation and mRNA but also increased
intracellular protein. DEX and IL-1 had additive effects on
annexin I mRNA, but DEX inhibited the inducing effect of
IL-1β on cell surface annexin I. These results indicate that
glucocorticoids and IL-1β upregulate the synthesis and
translocation of annexin I in RA FLS, but interdependent
signalling pathways are involved. |
| format | Article |
| id | doaj-art-67a05823397d4ea09373ff0ce86e61ab |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-67a05823397d4ea09373ff0ce86e61ab2025-02-03T06:42:04ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/7383573835Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1Eric F. Morand0Pam Hall1Paul Hutchinson2Yuan H. Yang3Centre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Locked Bag No 29, Clayton, Victoria 3168, AustraliaCentre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Locked Bag No 29, Clayton, Victoria 3168, AustraliaCentre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Locked Bag No 29, Clayton, Victoria 3168, AustraliaCentre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Locked Bag No 29, Clayton, Victoria 3168, AustraliaThe glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. DEX increased FLS annexin I protein translocation and mRNA expression. Interleukin (IL)-1β also induced annexin I translocation and mRNA but also increased intracellular protein. DEX and IL-1 had additive effects on annexin I mRNA, but DEX inhibited the inducing effect of IL-1β on cell surface annexin I. These results indicate that glucocorticoids and IL-1β upregulate the synthesis and translocation of annexin I in RA FLS, but interdependent signalling pathways are involved.http://dx.doi.org/10.1155/MI/2006/73835 |
| spellingShingle | Eric F. Morand Pam Hall Paul Hutchinson Yuan H. Yang Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 Mediators of Inflammation |
| title | Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 |
| title_full | Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 |
| title_fullStr | Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 |
| title_full_unstemmed | Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 |
| title_short | Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 |
| title_sort | regulation of annexin i in rheumatoid synovial cells by glucocorticoids and interleukin 1 |
| url | http://dx.doi.org/10.1155/MI/2006/73835 |
| work_keys_str_mv | AT ericfmorand regulationofannexiniinrheumatoidsynovialcellsbyglucocorticoidsandinterleukin1 AT pamhall regulationofannexiniinrheumatoidsynovialcellsbyglucocorticoidsandinterleukin1 AT paulhutchinson regulationofannexiniinrheumatoidsynovialcellsbyglucocorticoidsandinterleukin1 AT yuanhyang regulationofannexiniinrheumatoidsynovialcellsbyglucocorticoidsandinterleukin1 |