Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1
The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and de...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/73835 |
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| Summary: | The glucocorticoid (GC)-induced antiinflammatory
molecule annexin I is expressed in leukocytes and has
antiinflammatory effects in animal models of arthritis, but the
expression of annexin I in rheumatoid arthritis (RA)
fibroblast-like synoviocytes (FLS) is unknown. We report the
constitutive and dexamethasone (DEX)-inducible expression of
annexin I in RA FLS. DEX increased FLS annexin I protein
translocation and mRNA expression. Interleukin (IL)-1β also induced annexin I translocation and mRNA but also increased
intracellular protein. DEX and IL-1 had additive effects on
annexin I mRNA, but DEX inhibited the inducing effect of
IL-1β on cell surface annexin I. These results indicate that
glucocorticoids and IL-1β upregulate the synthesis and
translocation of annexin I in RA FLS, but interdependent
signalling pathways are involved. |
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| ISSN: | 0962-9351 1466-1861 |