Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis
Aims: Changes to sleep, weight, and endocrine function are common in Alzheimer’s disease (AD) and Lewy-body dementia (LBD). The cause of these is not known, but they may be related to hypothalamic neurodegeneration. Our aim was to assess whether hypothalamic volume is reduced in people with AD and L...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-06-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425100975/type/journal_article |
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| _version_ | 1849387556820484096 |
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| author | Axel AS Laurell Sita N Shah Masoud Rahmati John T O’Brien Benjamin R Underwood |
| author_facet | Axel AS Laurell Sita N Shah Masoud Rahmati John T O’Brien Benjamin R Underwood |
| author_sort | Axel AS Laurell |
| collection | DOAJ |
| description | Aims: Changes to sleep, weight, and endocrine function are common in Alzheimer’s disease (AD) and Lewy-body dementia (LBD). The cause of these is not known, but they may be related to hypothalamic neurodegeneration. Our aim was to assess whether hypothalamic volume is reduced in people with AD and LBD, and whether hypothalamic volume is associated with these common symptoms. |
| format | Article |
| id | doaj-art-679caa3c1dec43fdb64a65edf25b401c |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-679caa3c1dec43fdb64a65edf25b401c2025-08-20T03:51:43ZengCambridge University PressBJPsych Open2056-47242025-06-0111S10S1010.1192/bjo.2025.10097Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-AnalysisAxel AS Laurell0Sita N Shah1Masoud Rahmati2John T O’Brien3Benjamin R Underwood41University of Cambridge, Cambridge, United Kingdom 2Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom1University of Cambridge, Cambridge, United Kingdom 2Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom3Aix-Marseille University, Marseille, France 4Lorestan University, Khoramabad, Iran, Islamic Republic of 5Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran, Islamic Republic of1University of Cambridge, Cambridge, United Kingdom 2Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom1University of Cambridge, Cambridge, United Kingdom 2Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United KingdomAims: Changes to sleep, weight, and endocrine function are common in Alzheimer’s disease (AD) and Lewy-body dementia (LBD). The cause of these is not known, but they may be related to hypothalamic neurodegeneration. Our aim was to assess whether hypothalamic volume is reduced in people with AD and LBD, and whether hypothalamic volume is associated with these common symptoms.https://www.cambridge.org/core/product/identifier/S2056472425100975/type/journal_article |
| spellingShingle | Axel AS Laurell Sita N Shah Masoud Rahmati John T O’Brien Benjamin R Underwood Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis BJPsych Open |
| title | Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis |
| title_full | Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis |
| title_fullStr | Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis |
| title_short | Hypothalamic Structure and Function in Alzheimer’s Disease and Lewy-Body Dementia: A Systematic Review and Meta-Analysis |
| title_sort | hypothalamic structure and function in alzheimer s disease and lewy body dementia a systematic review and meta analysis |
| url | https://www.cambridge.org/core/product/identifier/S2056472425100975/type/journal_article |
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