Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection
BackgroundPredicting clinical pregnancy outcomes in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) remains challenging owing to the unique characteristics of this patient group. Therefore, this study aimed to leverage exis...
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Frontiers Media S.A.
2025-06-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1618552/full |
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| author | Feng-Xia Liu Ka-Li Huang Shan-Jia Yi Hui Huang Ming-Hua Shi Xue-Fei Liang |
| author_facet | Feng-Xia Liu Ka-Li Huang Shan-Jia Yi Hui Huang Ming-Hua Shi Xue-Fei Liang |
| author_sort | Feng-Xia Liu |
| collection | DOAJ |
| description | BackgroundPredicting clinical pregnancy outcomes in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) remains challenging owing to the unique characteristics of this patient group. Therefore, this study aimed to leverage existing predictive models for pregnancy outcomes while integrating innovative strategies to develop and validate a visualization-based predictive model specifically designed for patients with DOR undergoing IVF/ICSI treatment.MethodsThis retrospective study analyzed data from 448 patients with DOR who underwent IVF/ICSI at Guangxi Zhuang Autonomous Region Reproductive Hospital from January 2019 to August 2023. We developed and internally validated a nomogram incorporating the ovarian sensitivity index (OSI), age, and controlled ovarian hyperstimulation (COH) protocol to predict clinical pregnancy outcomes. Receiver operating characteristic (ROC) analysis, univariate and least absolute shrinkage and selection operator (LASSO) regression analyses, and multivariate logistic regression were used to construct the model. The optimal cut-off value of the OSI for predicting clinical pregnancy was 1.135.ResultsThrough multivariate analysis, age, OSI, and COH protocol were identified as independent predictors. The developed nomogram demonstrated good discrimination with an area under the ROC curve of 0.744, along with satisfactory calibration and clinical utility.ConclusionThe developed nomogram can accurately predict clinical pregnancy outcomes in patients with DOR undergoing IVF/ICSI, potentially assisting clinicians in personalized counselling and improving outcomes in this challenging patient population. |
| format | Article |
| id | doaj-art-6795bd1e48dc41beb8a58a6b998bb81b |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-6795bd1e48dc41beb8a58a6b998bb81b2025-08-20T03:30:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.16185521618552Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injectionFeng-Xia LiuKa-Li HuangShan-Jia YiHui HuangMing-Hua ShiXue-Fei LiangBackgroundPredicting clinical pregnancy outcomes in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) remains challenging owing to the unique characteristics of this patient group. Therefore, this study aimed to leverage existing predictive models for pregnancy outcomes while integrating innovative strategies to develop and validate a visualization-based predictive model specifically designed for patients with DOR undergoing IVF/ICSI treatment.MethodsThis retrospective study analyzed data from 448 patients with DOR who underwent IVF/ICSI at Guangxi Zhuang Autonomous Region Reproductive Hospital from January 2019 to August 2023. We developed and internally validated a nomogram incorporating the ovarian sensitivity index (OSI), age, and controlled ovarian hyperstimulation (COH) protocol to predict clinical pregnancy outcomes. Receiver operating characteristic (ROC) analysis, univariate and least absolute shrinkage and selection operator (LASSO) regression analyses, and multivariate logistic regression were used to construct the model. The optimal cut-off value of the OSI for predicting clinical pregnancy was 1.135.ResultsThrough multivariate analysis, age, OSI, and COH protocol were identified as independent predictors. The developed nomogram demonstrated good discrimination with an area under the ROC curve of 0.744, along with satisfactory calibration and clinical utility.ConclusionThe developed nomogram can accurately predict clinical pregnancy outcomes in patients with DOR undergoing IVF/ICSI, potentially assisting clinicians in personalized counselling and improving outcomes in this challenging patient population.https://www.frontiersin.org/articles/10.3389/fmed.2025.1618552/fulldiminished ovarian reservein vitro fertilizationintracytoplasmic sperm injectionovarian sensitivity indexnomogram |
| spellingShingle | Feng-Xia Liu Ka-Li Huang Shan-Jia Yi Hui Huang Ming-Hua Shi Xue-Fei Liang Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection Frontiers in Medicine diminished ovarian reserve in vitro fertilization intracytoplasmic sperm injection ovarian sensitivity index nomogram |
| title | Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection |
| title_full | Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection |
| title_fullStr | Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection |
| title_full_unstemmed | Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection |
| title_short | Ovarian sensitivity index-based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection |
| title_sort | ovarian sensitivity index based nomogram for predicting clinical pregnancy outcomes in patients with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection |
| topic | diminished ovarian reserve in vitro fertilization intracytoplasmic sperm injection ovarian sensitivity index nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1618552/full |
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