The paradox of hnRNPK: both absence and excess impair skeletal muscle function in mice

The paradox of hnRNPK: both absence and excess impair skeletal muscle function in mice

Abstract Background The RNA-binding protein hnRNPK is essential for animal growth and development, with a particular emphasis in myogenesis. Despite its importance, the precise mechanisms by which hnRNPK influences skeletal muscle physiology and development remain inadequately characterized. Methods...

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Main Authors: Yongjie Xu, Yuxi Wang, Xiaofang Cheng, Mengjia Zhang, Nuo Chen, Jiahua Guo, Yueru Huang, Quanxi Li, Tianyu Li, Tiantian Meng, Cencen Li, Pengpeng Zhang, Haixia Xu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Skeletal Muscle
Subjects:
HnRNPK
Skeletal muscle
Knockout
Overexpression
Mice
Muscle atrophy
Online Access:https://doi.org/10.1186/s13395-025-00393-3
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