Impact of changes in conventional risk factors induced by once-weekly GLP-1 receptor agonist exenatide on cardiovascular outcomes: an EXSCEL post hoc analysis

Impact of changes in conventional risk factors induced by once-weekly GLP-1 receptor agonist exenatide on cardiovascular outcomes: an EXSCEL post hoc analysis

Abstract Background The objective of this study was to examine the degree to which conventional cardiovascular (CV) risk factor changes induced by once-weekly exenatide (EQW) might explain the placebo-controlled differences in CV outcomes observed in the Exenatide Study of Cardiovascular Event Lower...

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Bibliographic Details
Main Authors: Ruth L. Coleman, Amanda I. Adler, Robert J. Mentz, Marat Fudim, Naveed Sattar, Rury R. Holman
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cardiovascular Diabetology
Subjects:
Glucagon-like peptide-1 receptor agonists
Once-weekly exenatide
Cardiovascular risk factors
Cardiovascular outcomes
Model simulation
Mediation analyses
Online Access:https://doi.org/10.1186/s12933-025-02866-7
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