Stability indicating RP-HPLC technique for simultaneous estimation of nirmatrelvir and ritonavir in their new copackaged dosage form for COVID-19 treatment

Stability indicating RP-HPLC technique for simultaneous estimation of nirmatrelvir and ritonavir in their new copackaged dosage form for COVID-19 treatment

Abstract RP-HPLC technique was developed and optimized for simultaneous identification and estimation of nirmatrelvir (NIR) and ritonavir (RIT) in their new copackaged tablet. Stability of nirmatrelvir (NIR) was studied after exposure to different five stress conditions; alkali, acid, heat, photo an...

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Bibliographic Details
Main Authors: Mohamed G. Yassin, Aya Roshdy, Aya A. Marie
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Nirmatrelvir (NIR)
Ritonavir (RIT)
RP-HPLC
Stability indicating
Copackaged tablet
Online Access:https://doi.org/10.1038/s41598-025-85776-8
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