GABAB receptors regulate the neural stem cell potential of Pkd2l1+ cerebrospinal fluid-contacting neurons via the PI3K/Akt signaling pathway

GABAB receptors regulate the neural stem cell potential of Pkd2l1+ cerebrospinal fluid-contacting neurons via the PI3K/Akt signaling pathway

Cerebrospinal fluid-contacting neurons (CSF-cNs) exhibit neural stem cell (NSC) properties both in vitro and in vivo, and they may play a critical role in recovery after spinal cord injury (SCI). GABAB receptors (GABABRs) are expressed in Pkd2l1+ CSF-cNs. However, their role in Pkd2l1+ CSF-cNs still...

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Bibliographic Details
Main Authors: Liang Cao, Wei-Hong Yan, Wenjun Pi, Yi Zhang, Yan-Xiang Xiong, V. Wee Yong, Mengzhou Xue, Qing Li, Chunfu Zheng, Leiluo Yang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Brain Research Bulletin
Subjects:
Spinal cord injury
Pkd2l1
Neural stem cells
GABAB receptors
CSF-cNs
PI3K/Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025000292
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