Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype

Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype

Abstract Background Colorectal cancer (CRC) frequently metastasizes to the liver, worsening patient outcomes. The formation of a pre-metastatic niche (PMN) is essential for this process, but how the primary colon tumor orchestrates the PMN formation remains unclear. Methods This study investigated t...

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Bibliographic Details
Main Authors: ShuJie Li, Xue Fu, Deng Ning, QiuMeng Liu, JunFang Zhao, Qi Cheng, XiaoPing Chen, Li Jiang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Biology Direct
Subjects:
Colon cancer
Pre-metastatic Nich
Exosome
Macrophage polarization
HSP90B1
Online Access:https://doi.org/10.1186/s13062-025-00623-0
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