Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women
Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood di...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000932 |
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| author | Stephen J. Carter Tyler H. Blechschmid Emily B. Long Tenzin Yangchen Marissa N. Baranauskas Chad C. Wiggins John S. Raglin Andrew R. Coggan |
| author_facet | Stephen J. Carter Tyler H. Blechschmid Emily B. Long Tenzin Yangchen Marissa N. Baranauskas Chad C. Wiggins John S. Raglin Andrew R. Coggan |
| author_sort | Stephen J. Carter |
| collection | DOAJ |
| description | Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m2; n = 14) or older (≥65 y; 81.8 ± 10.4 kg/m2; n = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O2peak). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O2). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O2. However, older women had lower aerobic capacity (p = 0.002, ES = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (p = 0.042, ES = 0.41). Among all participants, and independent of V̇O2peak, MRT correlated with average daily fatigue (r = 0.500, p = 0.015), fatigue interference (r = 0.421, p = 0.046), and POMS total mood disturbance (rs = 0.437, p = 0.037). Regression modeling revealed MRT and walking net V̇O2 jointly explained 55 % (R = 0.744, p < 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O2 may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women. |
| format | Article |
| id | doaj-art-677bb5ad272d4d489f695aacfec252b2 |
| institution | OA Journals |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-677bb5ad272d4d489f695aacfec252b22025-08-20T02:27:10ZengElsevierExperimental Gerontology1873-68152025-06-0120511276410.1016/j.exger.2025.112764Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal womenStephen J. Carter0Tyler H. Blechschmid1Emily B. Long2Tenzin Yangchen3Marissa N. Baranauskas4Chad C. Wiggins5John S. Raglin6Andrew R. Coggan7Department of Kinesiology, School of Public Health – Bloomington, Indiana University, Bloomington, IN 47405, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA; Corresponding author at: Department of Kinesiology, Indiana University, Bloomington, IN 47405-7109, USA.Department of Kinesiology, School of Public Health – Bloomington, Indiana University, Bloomington, IN 47405, USADepartment of Kinesiology, School of Public Health – Bloomington, Indiana University, Bloomington, IN 47405, USADepartment of Kinesiology, School of Public Health – Bloomington, Indiana University, Bloomington, IN 47405, USADepartment of Human Physiology & Nutrition, College of Nursing and Health Sciences, University of Colorado Colorado Springs, Colorado Spring, CO, USADepartment of Kinesiology, College of Education, Michigan State University, East Lansing, MI 48815, USADepartment of Kinesiology, School of Public Health – Bloomington, Indiana University, Bloomington, IN 47405, USADepartment of Kinesiology, School of Health and Human Sciences, Indiana University Indianapolis, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USAPostmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m2; n = 14) or older (≥65 y; 81.8 ± 10.4 kg/m2; n = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O2peak). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O2). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O2. However, older women had lower aerobic capacity (p = 0.002, ES = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (p = 0.042, ES = 0.41). Among all participants, and independent of V̇O2peak, MRT correlated with average daily fatigue (r = 0.500, p = 0.015), fatigue interference (r = 0.421, p = 0.046), and POMS total mood disturbance (rs = 0.437, p = 0.037). Regression modeling revealed MRT and walking net V̇O2 jointly explained 55 % (R = 0.744, p < 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O2 may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women.http://www.sciencedirect.com/science/article/pii/S0531556525000932AgingMean response timePhysical activityProfile of mood statesMenopauseWomen’s health |
| spellingShingle | Stephen J. Carter Tyler H. Blechschmid Emily B. Long Tenzin Yangchen Marissa N. Baranauskas Chad C. Wiggins John S. Raglin Andrew R. Coggan Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women Experimental Gerontology Aging Mean response time Physical activity Profile of mood states Menopause Women’s health |
| title | Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women |
| title_full | Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women |
| title_fullStr | Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women |
| title_full_unstemmed | Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women |
| title_short | Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women |
| title_sort | pulmonary vo2 on kinetics and walking net vo2 associate with fatigue and mood disturbance in postmenopausal women |
| topic | Aging Mean response time Physical activity Profile of mood states Menopause Women’s health |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000932 |
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