Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease
Abstract Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it originates from abnormal accumulation of triglycerides in the liver, and sometimes causes inflammatory react...
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.391 |
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| author | Yunfei Luo Hui Lin |
| author_facet | Yunfei Luo Hui Lin |
| author_sort | Yunfei Luo |
| collection | DOAJ |
| description | Abstract Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it originates from abnormal accumulation of triglycerides in the liver, and sometimes causes inflammatory reactions that could contribute to cirrhosis and liver cancer, thus its pathogenesis needs to be clarified for more treatment options. Once NAFLD is established, it contributes to systemic inflammation, the low‐grade inflammation is continuously maintained during NAFLD causing impaired resolution of inflammation in obesity, which subsequently exacerbates its severity. This study focuses on the effects of obesity‐induced inflammations, which are the underlying causes of the disease progression and development of more severe inflammatory and fibrotic stages. Understanding the relationship between obesity and NAFLD could help in establishing attractive therapeutic targets or diagnostic markers in obesity‐induced inflammation response and provides new approaches for the prevention and treatment of NAFLD in obesity. |
| format | Article |
| id | doaj-art-677a9f2e223d4c81a145e76deac0eb22 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-677a9f2e223d4c81a145e76deac0eb222025-08-20T02:15:41ZengWileyImmunity, Inflammation and Disease2050-45272021-03-0191597310.1002/iid3.391Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver diseaseYunfei Luo0Hui Lin1Department of Pathophysiology, Schools of Basic Sciences, Jiangxi Provincial Key Laboratory of Tumor Pathogens and Molecular Pathology Nanchang University Nanchang ChinaDepartment of Pathophysiology, Schools of Basic Sciences, Jiangxi Provincial Key Laboratory of Tumor Pathogens and Molecular Pathology Nanchang University Nanchang ChinaAbstract Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it originates from abnormal accumulation of triglycerides in the liver, and sometimes causes inflammatory reactions that could contribute to cirrhosis and liver cancer, thus its pathogenesis needs to be clarified for more treatment options. Once NAFLD is established, it contributes to systemic inflammation, the low‐grade inflammation is continuously maintained during NAFLD causing impaired resolution of inflammation in obesity, which subsequently exacerbates its severity. This study focuses on the effects of obesity‐induced inflammations, which are the underlying causes of the disease progression and development of more severe inflammatory and fibrotic stages. Understanding the relationship between obesity and NAFLD could help in establishing attractive therapeutic targets or diagnostic markers in obesity‐induced inflammation response and provides new approaches for the prevention and treatment of NAFLD in obesity.https://doi.org/10.1002/iid3.391adipose tissue inflammationNAFLDobesityobesity‐induced inflammation |
| spellingShingle | Yunfei Luo Hui Lin Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease Immunity, Inflammation and Disease adipose tissue inflammation NAFLD obesity obesity‐induced inflammation |
| title | Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease |
| title_full | Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease |
| title_fullStr | Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease |
| title_full_unstemmed | Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease |
| title_short | Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease |
| title_sort | inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease |
| topic | adipose tissue inflammation NAFLD obesity obesity‐induced inflammation |
| url | https://doi.org/10.1002/iid3.391 |
| work_keys_str_mv | AT yunfeiluo inflammationinitiatesaviciouscyclebetweenobesityandnonalcoholicfattyliverdisease AT huilin inflammationinitiatesaviciouscyclebetweenobesityandnonalcoholicfattyliverdisease |