Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study

Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study

Background Gut microbiota modulation is an emerging strategy to improve cancer therapy outcomes. This study evaluated the safety and therapeutic potential of combining oral vancomycin—a non-absorbed, gut-restricted antibiotic with primary activity against gram-positive bacteria—with stereotactic bod...

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Main Authors: Abigail Berman, Andrea Facciabene, Nikhil Yegya-Raman, Francesca Costabile, Costantinos Koumenis, Kyle Bittinger, Ceylan Tanes, Nektarios Kostopoulos, Amit Maity, Edgar Ben-Josef, Shane Lloyd, Steven Joel Feigenberg, Roderick O’Connor, Divyansh Agarwal, Giorgos Skoufos, Silavano Salaris, Artemis Hatzigeorgiou, Cole Friedes, Lisha Chen, Keith Cengel, William Levin, Bakir Valentić, Tyler Quarton, Alexander A Shestov, Jeffrey Bradley
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011356.full
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