CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses

CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses

Human cytomegalovirus (HCMV) infection is prevalent worldwide, and there is currently no licenced HCMV vaccine to control it. Therefore, developing an effective HCMV vaccine is a significant priority. Because of their excellent immunogenicity, the crucial components of HCMV, phosphoprotein 65 (pp65)...

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Main Authors: Shuyun Zhang, Fulong Nan, Shasha Jiang, Xiaoqiong Zhou, Delei Niu, Jun Li, Hui Wang, Xueming Zhang, Xianjuan Zhang, Bin Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Virulence
Subjects:
Human cytomegalovirus
peptide-CRM197 vaccine
antigen presentation
maturation of DCs
T cell immunity
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2023.2169488
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