Bacteriophage-driven microbial phenotypic heterogeneity: ecological and biogeochemical importance

Abstract Bacteriophages (phages) reprogram host metabolism and generate phenotypic heterogeneity, yet the mechanisms and ecological implications remain poorly understood representing a major knowledge gap in microbial ecology. This review explores how phage infection alters microbial physiology, con...

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Bibliographic Details
Main Authors: Xiaolong Liang, Shuo Yang, Mark Radosevich, Yongfeng Wang, Ning Duan, Yongfeng Jia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00727-5
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Summary:Abstract Bacteriophages (phages) reprogram host metabolism and generate phenotypic heterogeneity, yet the mechanisms and ecological implications remain poorly understood representing a major knowledge gap in microbial ecology. This review explores how phage infection alters microbial physiology, contributes to single-cell variation, and influences population dynamics. We highlight the potential consequences of phage-driven heterogeneity for microbial community structure and biogeochemical cycling, underscoring the importance of integrating phage-host interactions into ecological and ecosystem models.
ISSN:2055-5008