Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome
Background. One half of the patients with primary Sjögren’s syndrome has extraglandular manifestations, including renal involvement. The most frequent renal lesion is tubulo-interstitial nephritis, which manifests clinically as distal tubular acidosis and may result in the development of osteomalaci...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2005-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500510769J.pdf |
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| author | Jovelić Aleksandra Stefanović Dušan |
| author_facet | Jovelić Aleksandra Stefanović Dušan |
| author_sort | Jovelić Aleksandra |
| collection | DOAJ |
| description | Background. One half of the patients with primary Sjögren’s syndrome has extraglandular manifestations, including renal involvement. The most frequent renal lesion is tubulo-interstitial nephritis, which manifests clinically as distal tubular acidosis and may result in the development of osteomalacia. Case report. In a 29 - year-old female patient, with bilateral nephrolithiasis, the diagnosis of primary Sjögren’s syndrome, tubulo-interstitial nephritis, distal renal tubular acidosis, and hypokalemia were established. She was treated for hypokalemia. Two years later she developed bone pains and muscle weakness, she wasn’t able to walk, her proximal muscles and pelvic bones were painful, with radiological signs of pelvic bones osteopenia and pubic bones fractures. The diagnosis of osteomalacia was established and the treatment started with Schol’s solution, vitamin D and calcium. In the following two months, acidosis was corrected, and the patient started walking. Conclusion. In our patient with primary Sjögren’s syndrome and interstitial nephritis, osteomalacia was a result of the long time decompensate acidosis, so the correction of acidosis, and the supplementation of vitamin D and calcium were the integral part of the therapy. |
| format | Article |
| id | doaj-art-677304f31ebb40ff8a1f4e2e9fac0c35 |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-677304f31ebb40ff8a1f4e2e9fac0c352025-08-20T03:34:09ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502005-01-01621076977310.2298/VSP0510769JDistal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndromeJovelić AleksandraStefanović DušanBackground. One half of the patients with primary Sjögren’s syndrome has extraglandular manifestations, including renal involvement. The most frequent renal lesion is tubulo-interstitial nephritis, which manifests clinically as distal tubular acidosis and may result in the development of osteomalacia. Case report. In a 29 - year-old female patient, with bilateral nephrolithiasis, the diagnosis of primary Sjögren’s syndrome, tubulo-interstitial nephritis, distal renal tubular acidosis, and hypokalemia were established. She was treated for hypokalemia. Two years later she developed bone pains and muscle weakness, she wasn’t able to walk, her proximal muscles and pelvic bones were painful, with radiological signs of pelvic bones osteopenia and pubic bones fractures. The diagnosis of osteomalacia was established and the treatment started with Schol’s solution, vitamin D and calcium. In the following two months, acidosis was corrected, and the patient started walking. Conclusion. In our patient with primary Sjögren’s syndrome and interstitial nephritis, osteomalacia was a result of the long time decompensate acidosis, so the correction of acidosis, and the supplementation of vitamin D and calcium were the integral part of the therapy.http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500510769J.pdfosteomalaciaSjögren's syndromenephritisinterstitialisacidosisdiagnosistreatmentoutcome |
| spellingShingle | Jovelić Aleksandra Stefanović Dušan Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome Vojnosanitetski Pregled osteomalacia Sjögren's syndrome nephritis interstitialis acidosis diagnosis treatmentoutcome |
| title | Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome |
| title_full | Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome |
| title_fullStr | Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome |
| title_full_unstemmed | Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome |
| title_short | Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome |
| title_sort | distal renal tubular acidosis as a cause of osteomalacia in a patient with primary sjogren s syndrome |
| topic | osteomalacia Sjögren's syndrome nephritis interstitialis acidosis diagnosis treatmentoutcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500510769J.pdf |
| work_keys_str_mv | AT jovelicaleksandra distalrenaltubularacidosisasacauseofosteomalaciainapatientwithprimarysjogrenssyndrome AT stefanovicdusan distalrenaltubularacidosisasacauseofosteomalaciainapatientwithprimarysjogrenssyndrome |