Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study
Background. Transcatheter arterial lipiodol chemoembolization (TACE) can be used in cirrhotic patients with hepatocellular carcinoma to avoid tumor progression before transplantation. Objective. To evaluate the efficacy and safety of TACE used as a bridge to liver transplantation. Methods. TACE was...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.4061/2011/974514 |
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| author | Antoine Bouchard-Fortier Réal Lapointe Pierre Perreault Louis Bouchard Gilles Pomier-Layrargues |
| author_facet | Antoine Bouchard-Fortier Réal Lapointe Pierre Perreault Louis Bouchard Gilles Pomier-Layrargues |
| author_sort | Antoine Bouchard-Fortier |
| collection | DOAJ |
| description | Background. Transcatheter arterial lipiodol chemoembolization (TACE) can be used in cirrhotic patients with hepatocellular carcinoma to avoid tumor progression before transplantation. Objective. To evaluate the efficacy and safety of TACE used as a bridge to liver transplantation. Methods. TACE was performed in 30 cirrhotic patients with hepatocellular carcinoma. Milan criteria were used to select patients for transplant. Patients had a good or moderately impaired liver function, no arterioportal fistulae, and a good portal perfusion. Results. 48 TACE were performed in 30 patients. Before transplantation, 4 patients were dropped off the list due to tumor extension or liver failure. Complete necrosis of the tumor was observed in 11 patients and partial necrosis in 15 patients. After transplantation, 6 patients died and tumor recurrence was observed in 5 patients with a tumor beyond Milan criteria or no response to TACE. Conclusion. TACE is useful as a bridge to liver transplantation in a selected group of cirrhotic patients with hepatocellular carcinoma. A combined therapeutic approach before surgery might improve the prognosis in these patients. |
| format | Article |
| id | doaj-art-6763e0dbec1f414d9b93bd4d8e0b79be |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-6763e0dbec1f414d9b93bd4d8e0b79be2025-08-20T02:35:19ZengWileyInternational Journal of Hepatology2090-34482090-34562011-01-01201110.4061/2011/974514974514Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective StudyAntoine Bouchard-Fortier0Réal Lapointe1Pierre Perreault2Louis Bouchard3Gilles Pomier-Layrargues4Department of Surgery, Centre Hospitalier de l'Université de Montréal, 264, East René-Lévesque Blvd, 3rd floor, Montreal, QC, H2X 1P1, CanadaDepartment of Surgery, Centre Hospitalier de l'Université de Montréal, 264, East René-Lévesque Blvd, 3rd floor, Montreal, QC, H2X 1P1, CanadaDepartment of Radiology, Centre Hospitalier de l'Université de Montréal, 264, East René-Lévesque Blvd, 3rd floor, Montreal, QC, H2X 1P1, CanadaDepartment of Radiology, Centre Hospitalier de l'Université de Montréal, 264, East René-Lévesque Blvd, 3rd floor, Montreal, QC, H2X 1P1, CanadaLiver Unit, Centre Hospitalier de l'Université de Montréal, 264, East René-Lévesque Blvd, 3rd floor, Montreal, QC, H2X 1P1, CanadaBackground. Transcatheter arterial lipiodol chemoembolization (TACE) can be used in cirrhotic patients with hepatocellular carcinoma to avoid tumor progression before transplantation. Objective. To evaluate the efficacy and safety of TACE used as a bridge to liver transplantation. Methods. TACE was performed in 30 cirrhotic patients with hepatocellular carcinoma. Milan criteria were used to select patients for transplant. Patients had a good or moderately impaired liver function, no arterioportal fistulae, and a good portal perfusion. Results. 48 TACE were performed in 30 patients. Before transplantation, 4 patients were dropped off the list due to tumor extension or liver failure. Complete necrosis of the tumor was observed in 11 patients and partial necrosis in 15 patients. After transplantation, 6 patients died and tumor recurrence was observed in 5 patients with a tumor beyond Milan criteria or no response to TACE. Conclusion. TACE is useful as a bridge to liver transplantation in a selected group of cirrhotic patients with hepatocellular carcinoma. A combined therapeutic approach before surgery might improve the prognosis in these patients.http://dx.doi.org/10.4061/2011/974514 |
| spellingShingle | Antoine Bouchard-Fortier Réal Lapointe Pierre Perreault Louis Bouchard Gilles Pomier-Layrargues Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study International Journal of Hepatology |
| title | Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study |
| title_full | Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study |
| title_fullStr | Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study |
| title_full_unstemmed | Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study |
| title_short | Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma as a Bridge to Liver Transplantation: A Retrospective Study |
| title_sort | transcatheter arterial chemoembolization of hepatocellular carcinoma as a bridge to liver transplantation a retrospective study |
| url | http://dx.doi.org/10.4061/2011/974514 |
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