Matrilin-2 with a K-Chitosan Scaffold Enhances Functional Recovery and Nerve Regeneration in a Segmental Rat Sciatic Nerve Injury Model

Matrilin-2 with a K-Chitosan Scaffold Enhances Functional Recovery and Nerve Regeneration in a Segmental Rat Sciatic Nerve Injury Model

<b>Background/Objectives:</b> Previous work in our lab demonstrated that a 3D scaffold containing lysine-modified chitosan (K-chitosan) and decorated with Matrilin-2 (MATN2) enhanced Schwann cell (SC) migration and axonal outgrowth in vitro and ex vivo. This study aimed to assess the reg...

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Bibliographic Details
Main Authors: Neill Y. Li, Brandon Vorrius, Elliott Rebello, Jonathan Ge, Amit Mohite, Zhen Qiao, Jing Ding, Qian Chen
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
matrilin-2
peripheral nerve repair
nerve reconstruction
reverse autograft
electrophysiology
axonal histomorphometry
Online Access:https://www.mdpi.com/1424-8247/18/5/686
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