Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans
Abstract Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgical evaluation of epileptic patients. Nevertheless, the cortical generators underly...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-06-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-62433-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181650535677952 |
|---|---|
| author | Boglárka Hajnal Johanna Petra Szabó Emília Tóth Corey J. Keller Lucia Wittner Ashesh D. Mehta Loránd Erőss István Ulbert Dániel Fabó László Entz |
| author_facet | Boglárka Hajnal Johanna Petra Szabó Emília Tóth Corey J. Keller Lucia Wittner Ashesh D. Mehta Loránd Erőss István Ulbert Dániel Fabó László Entz |
| author_sort | Boglárka Hajnal |
| collection | DOAJ |
| description | Abstract Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgical evaluation of epileptic patients. Nevertheless, the cortical generators underlying the various components of CCEPs in humans have not yet been elucidated. Our aim was to describe the laminar pattern arising under SPES evoked CCEP components (P1, N1, P2, N2, P3) and to evaluate the similarities between N2 and the downstate of sleep slow waves. We used intra-cortical laminar microelectrodes (LMEs) to record CCEPs evoked by 10 mA bipolar 0.5 Hz electric pulses in seven patients with medically intractable epilepsy implanted with subdural grids. Based on the laminar profile of CCEPs, the latency of components is not layer-dependent, however their rate of appearance varies across cortical depth and stimulation distance, while the seizure onset zone does not seem to affect the emergence of components. Early neural excitation primarily engages middle and deep layers, propagating to the superficial layers, followed by mainly superficial inhibition, concluding in a sleep slow wave-like inhibition and excitation sequence. |
| format | Article |
| id | doaj-art-675b29cbc830488cb999decfcf2537f4 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-675b29cbc830488cb999decfcf2537f42025-08-20T02:17:50ZengNature PortfolioScientific Reports2045-23222024-06-0114111710.1038/s41598-024-62433-0Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humansBoglárka Hajnal0Johanna Petra Szabó1Emília Tóth2Corey J. Keller3Lucia Wittner4Ashesh D. Mehta5Loránd Erőss6István Ulbert7Dániel Fabó8László Entz9Epilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis UniversityEpilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis UniversityEpilepsy and Cognitive Neurophysiology Laboratory, University of Alabama at BirminghamDepartment of Neuroscience, Albert Einstein College of MedicineInstitute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, HUN-RENDepartment of Neurosurgery, Hofstra North Shore LIJ School of Medicine and Feinstein Institute of Medical ResearchDepartment of Functional Neurosurgery, Clinic for Neurosurgery and Neurointervention, Semmelweis UniversityEpilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis UniversityEpilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis UniversityDepartment of Functional Neurosurgery, Clinic for Neurosurgery and Neurointervention, Semmelweis UniversityAbstract Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgical evaluation of epileptic patients. Nevertheless, the cortical generators underlying the various components of CCEPs in humans have not yet been elucidated. Our aim was to describe the laminar pattern arising under SPES evoked CCEP components (P1, N1, P2, N2, P3) and to evaluate the similarities between N2 and the downstate of sleep slow waves. We used intra-cortical laminar microelectrodes (LMEs) to record CCEPs evoked by 10 mA bipolar 0.5 Hz electric pulses in seven patients with medically intractable epilepsy implanted with subdural grids. Based on the laminar profile of CCEPs, the latency of components is not layer-dependent, however their rate of appearance varies across cortical depth and stimulation distance, while the seizure onset zone does not seem to affect the emergence of components. Early neural excitation primarily engages middle and deep layers, propagating to the superficial layers, followed by mainly superficial inhibition, concluding in a sleep slow wave-like inhibition and excitation sequence.https://doi.org/10.1038/s41598-024-62433-0 |
| spellingShingle | Boglárka Hajnal Johanna Petra Szabó Emília Tóth Corey J. Keller Lucia Wittner Ashesh D. Mehta Loránd Erőss István Ulbert Dániel Fabó László Entz Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans Scientific Reports |
| title | Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans |
| title_full | Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans |
| title_fullStr | Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans |
| title_full_unstemmed | Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans |
| title_short | Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans |
| title_sort | intracortical mechanisms of single pulse electrical stimulation spes evoked excitations and inhibitions in humans |
| url | https://doi.org/10.1038/s41598-024-62433-0 |
| work_keys_str_mv | AT boglarkahajnal intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT johannapetraszabo intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT emiliatoth intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT coreyjkeller intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT luciawittner intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT asheshdmehta intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT lorandeross intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT istvanulbert intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT danielfabo intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans AT laszloentz intracorticalmechanismsofsinglepulseelectricalstimulationspesevokedexcitationsandinhibitionsinhumans |