Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome

Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome

IntroductionUnfolded Von Willebrand Factor (VWF) is increased in thrombotic pathologies such as myocardial infarction. Unfolded VWF mediates the binding of platelets without the need for collagen. β2-glycoprotein I (β2-GPI) is a natural inhibitor of the platelet-VWF interaction. The antiphospholipid...

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Bibliographic Details
Main Authors: Romy de Laat-Kremers, Shengshi Huang, Hugo ten Cate, Marisa Ninivaggi, Bas de Laat, Katrien Devreese
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
Von Willbrand Factor
antiphospholipid syndrome
thrombosis
unfolded VWF
VWF pro-peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1514433/full
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