Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications
Parkinson's disease (PD), the second most common neurodegenerative disorder, currently lacks disease-modifying treatments. The conventional therapeutic approach, which focuses on targeting individual molecules, falls short in addressing the complex pathology of PD. Cistanches Herba, a medicinal...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Agriculture and Food Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154325000420 |
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| author | Guoxue Zhu Chengcheng Xu Shujun Jiang Zhennian Zhang Wang Wang |
| author_facet | Guoxue Zhu Chengcheng Xu Shujun Jiang Zhennian Zhang Wang Wang |
| author_sort | Guoxue Zhu |
| collection | DOAJ |
| description | Parkinson's disease (PD), the second most common neurodegenerative disorder, currently lacks disease-modifying treatments. The conventional therapeutic approach, which focuses on targeting individual molecules, falls short in addressing the complex pathology of PD. Cistanches Herba, a medicinal herb also recognized as a functional food, has shown therapeutic potential in mitigating PD and its associated complications through various mechanisms. In this review, we conducted thorough searches across PubMed and Web of Science using a range of keywords such as ''Parkinson's disease,'' ''Cistanches Herba,'' ''Medicine Food Homology,'' ''chemical component,'' ''prescriptions,'' ''complications,'' ''mechanism,'' ''safety,'' and ''toxicity,'' as well as different keyword combinations. Our findings indicate that Cistanches Herba, along with its active compounds and formulations, exerts therapeutic effects in PD through neuroprotection, anti-inflammatory activity, and other mechanisms. This multi-component, multi-target strategy underscores the herb's broad therapeutic potential. Additionally, we critically assess the safety and toxicity profile of Cistanches Herba, laying the groundwork for its safe and effective clinical application. This review offers a comprehensive overview of the pharmacological properties of Cistanches Herba in treating PD and its complications, providing new insights into its therapeutic potential and contributing to the expanding body of research on PD. |
| format | Article |
| id | doaj-art-67552a911dbd45beb802b6400b7bd58f |
| institution | DOAJ |
| issn | 2666-1543 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Agriculture and Food Research |
| spelling | doaj-art-67552a911dbd45beb802b6400b7bd58f2025-08-20T03:04:58ZengElsevierJournal of Agriculture and Food Research2666-15432025-03-011910167110.1016/j.jafr.2025.101671Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complicationsGuoxue Zhu0Chengcheng Xu1Shujun Jiang2Zhennian Zhang3Wang Wang4Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Corresponding author.School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Corresponding author.Parkinson's disease (PD), the second most common neurodegenerative disorder, currently lacks disease-modifying treatments. The conventional therapeutic approach, which focuses on targeting individual molecules, falls short in addressing the complex pathology of PD. Cistanches Herba, a medicinal herb also recognized as a functional food, has shown therapeutic potential in mitigating PD and its associated complications through various mechanisms. In this review, we conducted thorough searches across PubMed and Web of Science using a range of keywords such as ''Parkinson's disease,'' ''Cistanches Herba,'' ''Medicine Food Homology,'' ''chemical component,'' ''prescriptions,'' ''complications,'' ''mechanism,'' ''safety,'' and ''toxicity,'' as well as different keyword combinations. Our findings indicate that Cistanches Herba, along with its active compounds and formulations, exerts therapeutic effects in PD through neuroprotection, anti-inflammatory activity, and other mechanisms. This multi-component, multi-target strategy underscores the herb's broad therapeutic potential. Additionally, we critically assess the safety and toxicity profile of Cistanches Herba, laying the groundwork for its safe and effective clinical application. This review offers a comprehensive overview of the pharmacological properties of Cistanches Herba in treating PD and its complications, providing new insights into its therapeutic potential and contributing to the expanding body of research on PD.http://www.sciencedirect.com/science/article/pii/S2666154325000420Parkinson's diseaseCistanches herbaMedicine food homologySafetyToxicity |
| spellingShingle | Guoxue Zhu Chengcheng Xu Shujun Jiang Zhennian Zhang Wang Wang Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications Journal of Agriculture and Food Research Parkinson's disease Cistanches herba Medicine food homology Safety Toxicity |
| title | Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications |
| title_full | Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications |
| title_fullStr | Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications |
| title_full_unstemmed | Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications |
| title_short | Medicinal and food plant: Cistanches Herba, a potential therapeutic hope for Parkinson's disease and related complications |
| title_sort | medicinal and food plant cistanches herba a potential therapeutic hope for parkinson s disease and related complications |
| topic | Parkinson's disease Cistanches herba Medicine food homology Safety Toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2666154325000420 |
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