Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study
<i>Fucus vesiculosus</i> is a brown seaweed known for its strong antioxidant properties, mainly attributed to its high polyphenolic content. This study aimed to evaluate the antioxidant protective effect of an optimised <i>F. vesiculosus</i> extract in an experimental model o...
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2025-05-01
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| Series: | Antioxidants |
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| author | Desirée Sánchez-Bonet Carolina Padrón-Sanz José Miguel Lloris-Cejalvo José Miguel Lloris-Carsí Dolores Cejalvo-Lapeña |
| author_facet | Desirée Sánchez-Bonet Carolina Padrón-Sanz José Miguel Lloris-Cejalvo José Miguel Lloris-Carsí Dolores Cejalvo-Lapeña |
| author_sort | Desirée Sánchez-Bonet |
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| description | <i>Fucus vesiculosus</i> is a brown seaweed known for its strong antioxidant properties, mainly attributed to its high polyphenolic content. This study aimed to evaluate the antioxidant protective effect of an optimised <i>F. vesiculosus</i> extract in an experimental model of intestinal ischemia/reperfusion (I/R) injury, considering the intestine as particularly vulnerable to this pathology. Seventy-two male Wistar albino rats were randomly divided into twelve groups: Sham, I/R groups (3 and 24 h reperfusion), I/R plus vehicle groups (three application times, 3 h reperfusion), and I/R plus <i>F. vesiculosus</i> extract groups (three application times, 3 and 24 h reperfusion). Intestinal injury was assessed through biochemical markers (malondialdehyde [MDA], superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and mieloperoxidase [MPO]), inflammatory cytokines (interleukin 1 β [IL-1β] and interleukin [IL-10]), and histological analysis. Results demonstrated that treatment with <i>F. vesiculosus</i> significantly reduced oxidative stress and inflammation caused by I/R injury (<i>p</i> < 0.05), restoring analysed parameters (MDA, SOD, CAT, IL-10) to levels comparable to the Sham group. Histological examination confirmed the preservation of intestinal mucosal integrity following <i>F. vesiculosus</i> administration. These findings suggest that the antioxidant extract from <i>F. vesiculosus</i> effectively protects against intestinal I/R injury, highlighting its potential for clinical use in preventing and managing this pathological condition, particularly in surgical contexts. |
| format | Article |
| id | doaj-art-674f1c6dadf64b7cafa50b2bb1361cd3 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-674f1c6dadf64b7cafa50b2bb1361cd32025-08-20T03:32:26ZengMDPI AGAntioxidants2076-39212025-05-0114662410.3390/antiox14060624Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological StudyDesirée Sánchez-Bonet0Carolina Padrón-Sanz1José Miguel Lloris-Cejalvo2José Miguel Lloris-Carsí3Dolores Cejalvo-Lapeña4Escuela de Doctorado, Universidad Católica de Valencia “San Vicente Mártir”, Plaza de San Agustín, 3, 46001 Valencia, SpainCentro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia “San Vicente Mártir”, C/Quevedo, 2, 46001 Valencia, SpainEscuela de Doctorado, Universidad Católica de Valencia “San Vicente Mártir”, Plaza de San Agustín, 3, 46001 Valencia, SpainFacultad de Medicina, Departamento de Cirugía, Universidad de Valencia, Avda. Blasco Ibáñez, 13, 46010 Valencia, SpainCentro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia “San Vicente Mártir”, C/Quevedo, 2, 46001 Valencia, Spain<i>Fucus vesiculosus</i> is a brown seaweed known for its strong antioxidant properties, mainly attributed to its high polyphenolic content. This study aimed to evaluate the antioxidant protective effect of an optimised <i>F. vesiculosus</i> extract in an experimental model of intestinal ischemia/reperfusion (I/R) injury, considering the intestine as particularly vulnerable to this pathology. Seventy-two male Wistar albino rats were randomly divided into twelve groups: Sham, I/R groups (3 and 24 h reperfusion), I/R plus vehicle groups (three application times, 3 h reperfusion), and I/R plus <i>F. vesiculosus</i> extract groups (three application times, 3 and 24 h reperfusion). Intestinal injury was assessed through biochemical markers (malondialdehyde [MDA], superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and mieloperoxidase [MPO]), inflammatory cytokines (interleukin 1 β [IL-1β] and interleukin [IL-10]), and histological analysis. Results demonstrated that treatment with <i>F. vesiculosus</i> significantly reduced oxidative stress and inflammation caused by I/R injury (<i>p</i> < 0.05), restoring analysed parameters (MDA, SOD, CAT, IL-10) to levels comparable to the Sham group. Histological examination confirmed the preservation of intestinal mucosal integrity following <i>F. vesiculosus</i> administration. These findings suggest that the antioxidant extract from <i>F. vesiculosus</i> effectively protects against intestinal I/R injury, highlighting its potential for clinical use in preventing and managing this pathological condition, particularly in surgical contexts.https://www.mdpi.com/2076-3921/14/6/624<i>Fucus vesiculosus</i>antioxidantpolyphenolsintestinal ischemia/reperfusion |
| spellingShingle | Desirée Sánchez-Bonet Carolina Padrón-Sanz José Miguel Lloris-Cejalvo José Miguel Lloris-Carsí Dolores Cejalvo-Lapeña Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study Antioxidants <i>Fucus vesiculosus</i> antioxidant polyphenols intestinal ischemia/reperfusion |
| title | Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study |
| title_full | Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study |
| title_fullStr | Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study |
| title_full_unstemmed | Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study |
| title_short | Antioxidant Effect of a <i>Fucus vesiculosus</i> Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study |
| title_sort | antioxidant effect of a i fucus vesiculosus i extract on intestinal ischemia reperfusion injury in rats a biochemical and histological study |
| topic | <i>Fucus vesiculosus</i> antioxidant polyphenols intestinal ischemia/reperfusion |
| url | https://www.mdpi.com/2076-3921/14/6/624 |
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