Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts
This study evaluated and compared the antimicrobial, antioxidant, anticholinesterase, and antidiabetic activities of Matricaria chamomilla L. (chamomile), Lavandula angustifolia Mill. (lavender), Hypericum perforatum L. (St. John’s wort), Salvia officinalis L. (sage), and Foeniculum vulgare Mill. (f...
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| Format: | Article |
| Language: | English |
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Hasan Eleroğlu
2025-07-01
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| Series: | Turkish Journal of Agriculture: Food Science and Technology |
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| Online Access: | https://agrifoodscience.com/index.php/TURJAF/article/view/7631 |
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| author | Meryem Uğurlu Hafize Yuca Furkan Çoban Bilge Aydın Gamze Göger Songül Karakaya |
| author_facet | Meryem Uğurlu Hafize Yuca Furkan Çoban Bilge Aydın Gamze Göger Songül Karakaya |
| author_sort | Meryem Uğurlu |
| collection | DOAJ |
| description | This study evaluated and compared the antimicrobial, antioxidant, anticholinesterase, and antidiabetic activities of Matricaria chamomilla L. (chamomile), Lavandula angustifolia Mill. (lavender), Hypericum perforatum L. (St. John’s wort), Salvia officinalis L. (sage), and Foeniculum vulgare Mill. (fennel) plants and their extracts. Antioxidant activity was assessed using DPPH and ABTS assays, while α-glucosidase and α-amylase inhibition assays determined antidiabetic potential. Acetylcholinesterase and butyrylcholinesterase inhibitory activities were measured via the Ellman method, and antimicrobial activity was evaluated using the micro-well dilution test. Among the tested extracts, H. perforatum extract and H. perforatum drug exhibited the most potent biological activities. In the α-glucosidase inhibition assay, H. perforatum extract displayed the highest inhibition (95.40%, IC₅₀ = 8 µg/mL), followed by H. perforatum drug (94.71%, IC₅₀ = 27 µg/mL). The strongest α-amylase inhibition was observed with the Soothing Complex Product (60.90%), following acarbose (74.61%). The highest ABTS radical scavenging activity was noted in S. officinalis drug (99.39%) and H. perforatum drug (99.32%), while the DPPH assay showed significant activity for S. officinalis extract (46.99%) and α-tocopherol (46.99%). Antimicrobial testing revealed moderate antibacterial effects of F. vulgare drug against Staphylococcus aureus and Candida albicans (MIC = 1250 µg/mL). Overall, H. perforatum extracts demonstrated strong enzyme inhibition and antioxidant properties, highlighting their potential for medicinal and dermocosmetic applications. These findings provide valuable insights into the bioactivity of herbal extracts, supporting their potential use in over-the-counter formulations and new plant-based therapeutic products. |
| format | Article |
| id | doaj-art-67460afd8ab845cfa09a0d88ddcf87dd |
| institution | Kabale University |
| issn | 2148-127X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Hasan Eleroğlu |
| record_format | Article |
| series | Turkish Journal of Agriculture: Food Science and Technology |
| spelling | doaj-art-67460afd8ab845cfa09a0d88ddcf87dd2025-08-20T03:34:53ZengHasan EleroğluTurkish Journal of Agriculture: Food Science and Technology2148-127X2025-07-011371854187110.24925/turjaf.v13i7.1854-1871.76316332Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare ExtractsMeryem Uğurlu0https://orcid.org/0009-0004-6006-1451Hafize Yuca1https://orcid.org/0000-0002-0857-4776Furkan Çoban2https://orcid.org/0000-0003-2815-8988Bilge Aydın3https://orcid.org/0000-0002-7712-7259Gamze Göger4https://orcid.org/0000-0003-2978-5385Songül Karakaya5https://orcid.org/0000-0002-3268-721XAtatürk University, Faculty of Pharmacy, Department of Pharmacognosy, 25040, Erzurum, Türkiye1Atatürk University, Faculty of Pharmacy, Department of Pharmacognosy, 25040, Erzurum, TürkiyeAtatürk University, Faculty of Agriculture, Department of Field Crops, 25040, Erzurum, TürkiyeErzincan Binali Yıldırım University, Faculty of Pharmacy, Department of Pharmacognosy, 24100, Erzincan, TürkiyeAfyonkarahisar Health Sciences University, Faculty of Pharmacy, Department of Pharmacognosy, 03030, Afyon, TürkiyeAtatürk University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 25040, Erzurum, TürkiyeThis study evaluated and compared the antimicrobial, antioxidant, anticholinesterase, and antidiabetic activities of Matricaria chamomilla L. (chamomile), Lavandula angustifolia Mill. (lavender), Hypericum perforatum L. (St. John’s wort), Salvia officinalis L. (sage), and Foeniculum vulgare Mill. (fennel) plants and their extracts. Antioxidant activity was assessed using DPPH and ABTS assays, while α-glucosidase and α-amylase inhibition assays determined antidiabetic potential. Acetylcholinesterase and butyrylcholinesterase inhibitory activities were measured via the Ellman method, and antimicrobial activity was evaluated using the micro-well dilution test. Among the tested extracts, H. perforatum extract and H. perforatum drug exhibited the most potent biological activities. In the α-glucosidase inhibition assay, H. perforatum extract displayed the highest inhibition (95.40%, IC₅₀ = 8 µg/mL), followed by H. perforatum drug (94.71%, IC₅₀ = 27 µg/mL). The strongest α-amylase inhibition was observed with the Soothing Complex Product (60.90%), following acarbose (74.61%). The highest ABTS radical scavenging activity was noted in S. officinalis drug (99.39%) and H. perforatum drug (99.32%), while the DPPH assay showed significant activity for S. officinalis extract (46.99%) and α-tocopherol (46.99%). Antimicrobial testing revealed moderate antibacterial effects of F. vulgare drug against Staphylococcus aureus and Candida albicans (MIC = 1250 µg/mL). Overall, H. perforatum extracts demonstrated strong enzyme inhibition and antioxidant properties, highlighting their potential for medicinal and dermocosmetic applications. These findings provide valuable insights into the bioactivity of herbal extracts, supporting their potential use in over-the-counter formulations and new plant-based therapeutic products.https://agrifoodscience.com/index.php/TURJAF/article/view/7631medicinal and aromatic plantherbal extractsbiological activitysoothing complex |
| spellingShingle | Meryem Uğurlu Hafize Yuca Furkan Çoban Bilge Aydın Gamze Göger Songül Karakaya Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts Turkish Journal of Agriculture: Food Science and Technology medicinal and aromatic plant herbal extracts biological activity soothing complex |
| title | Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts |
| title_full | Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts |
| title_fullStr | Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts |
| title_full_unstemmed | Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts |
| title_short | Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts |
| title_sort | evaluation of the antimicrobial antioxidant anticholinesterase and antidiabetic activities of matricaria chamomilla lavandula angustifolia hypericum perforatum salvia officinalis and foeniculum vulgare extracts |
| topic | medicinal and aromatic plant herbal extracts biological activity soothing complex |
| url | https://agrifoodscience.com/index.php/TURJAF/article/view/7631 |
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