Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation
Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes. Therefore, it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation. Here, we present evidence that Bakuchiol (BL), a monoterpene phen...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250052 |
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| author | Zhenhua Liu Xiaoqing Xu Zhenhua Liang Yixiao Chen Qiuyi Wang Wenyi Kang Yan Zhang Bin Cong |
| author_facet | Zhenhua Liu Xiaoqing Xu Zhenhua Liang Yixiao Chen Qiuyi Wang Wenyi Kang Yan Zhang Bin Cong |
| author_sort | Zhenhua Liu |
| collection | DOAJ |
| description | Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes. Therefore, it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation. Here, we present evidence that Bakuchiol (BL), a monoterpene phenolic compound first discovered from Psoralea corylifolia L. as traditional Chinese medicine, can effectively improve insulin resistance in diabetic mice through anti-inflammation. Our findings demonstrate that BL alleviates inflammation by inhibiting the toll-like receptor 4/nuclear factor κB/mitogen-activated protein kinase axis, consequently enhancing insulin receptor signaling through the c-Jun N-terminal kinase/suppressors of cytokine signaling 3/insulin receptor substrate1 pathway and improving glucolipid homeostasis. Furthermore, the insulin recovery achieved with BL (60 mg/kg) was comparable to that of metformin (200 mg/kg). These results provide further support for considering BL as a potential treatment option for insulin-resistant diabetes mellitus. |
| format | Article |
| id | doaj-art-67419a324f564d0ab488ffd564aafcee |
| institution | DOAJ |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-67419a324f564d0ab488ffd564aafcee2025-08-20T02:45:03ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363159317010.26599/FSHW.2023.9250052Bakuchiol ameliorates glycolipid homeostasis by reducing inflammationZhenhua Liu0Xiaoqing Xu1Zhenhua Liang2Yixiao Chen3Qiuyi Wang4Wenyi Kang5Yan Zhang6Bin Cong7National R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaHebei Key Laboratory of Forensic Medicine, College of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaInflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes. Therefore, it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation. Here, we present evidence that Bakuchiol (BL), a monoterpene phenolic compound first discovered from Psoralea corylifolia L. as traditional Chinese medicine, can effectively improve insulin resistance in diabetic mice through anti-inflammation. Our findings demonstrate that BL alleviates inflammation by inhibiting the toll-like receptor 4/nuclear factor κB/mitogen-activated protein kinase axis, consequently enhancing insulin receptor signaling through the c-Jun N-terminal kinase/suppressors of cytokine signaling 3/insulin receptor substrate1 pathway and improving glucolipid homeostasis. Furthermore, the insulin recovery achieved with BL (60 mg/kg) was comparable to that of metformin (200 mg/kg). These results provide further support for considering BL as a potential treatment option for insulin-resistant diabetes mellitus.https://www.sciopen.com/article/10.26599/FSHW.2023.9250052bakuchioldiabetesinsulin resistanceproteomicinflammation |
| spellingShingle | Zhenhua Liu Xiaoqing Xu Zhenhua Liang Yixiao Chen Qiuyi Wang Wenyi Kang Yan Zhang Bin Cong Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation Food Science and Human Wellness bakuchiol diabetes insulin resistance proteomic inflammation |
| title | Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation |
| title_full | Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation |
| title_fullStr | Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation |
| title_full_unstemmed | Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation |
| title_short | Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation |
| title_sort | bakuchiol ameliorates glycolipid homeostasis by reducing inflammation |
| topic | bakuchiol diabetes insulin resistance proteomic inflammation |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250052 |
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