Supramolecular Biopolymers for Tissue Engineering
Supramolecular biopolymers (SBPs) are those polymeric units derived from macromolecules that can assemble with each other by noncovalent interactions. Macromolecular structures are commonly found in living systems such as proteins, DNA/RNA, and polysaccharides. Bioorganic chemistry allows the genera...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2021/8815006 |
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| _version_ | 1832546879410274304 |
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| author | Rosario Pérez-Pedroza Alan Ávila-Ramírez Zainab Khan Manola Moretti Charlotte A. E. Hauser |
| author_facet | Rosario Pérez-Pedroza Alan Ávila-Ramírez Zainab Khan Manola Moretti Charlotte A. E. Hauser |
| author_sort | Rosario Pérez-Pedroza |
| collection | DOAJ |
| description | Supramolecular biopolymers (SBPs) are those polymeric units derived from macromolecules that can assemble with each other by noncovalent interactions. Macromolecular structures are commonly found in living systems such as proteins, DNA/RNA, and polysaccharides. Bioorganic chemistry allows the generation of sequence-specific supramolecular units like SBPs that can be tailored for novel applications in tissue engineering (TE). SBPs hold advantages over other conventional polymers previously used for TE; these materials can be easily functionalized; they are self-healing, biodegradable, stimuli-responsive, and nonimmunogenic. These characteristics are vital for the further development of current trends in TE, such as the use of pluripotent cells for organoid generation, cell-free scaffolds for tissue regeneration, patient-derived organ models, and controlled delivery systems of small molecules. In this review, we will analyse the 3 subtypes of SBPs: peptide-, nucleic acid-, and oligosaccharide-derived. Then, we will discuss the role that SBPs will be playing in TE as dynamic scaffolds, therapeutic scaffolds, and bioinks. Finally, we will describe possible outlooks of SBPs for TE. |
| format | Article |
| id | doaj-art-673f2229e08a429a85e18a352f4535c7 |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-673f2229e08a429a85e18a352f4535c72025-02-03T06:46:42ZengWileyAdvances in Polymer Technology0730-66791098-23292021-01-01202110.1155/2021/88150068815006Supramolecular Biopolymers for Tissue EngineeringRosario Pérez-Pedroza0Alan Ávila-Ramírez1Zainab Khan2Manola Moretti3Charlotte A. E. Hauser4Laboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi ArabiaLaboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi ArabiaBeacon Development, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi ArabiaLaboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi ArabiaLaboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi ArabiaSupramolecular biopolymers (SBPs) are those polymeric units derived from macromolecules that can assemble with each other by noncovalent interactions. Macromolecular structures are commonly found in living systems such as proteins, DNA/RNA, and polysaccharides. Bioorganic chemistry allows the generation of sequence-specific supramolecular units like SBPs that can be tailored for novel applications in tissue engineering (TE). SBPs hold advantages over other conventional polymers previously used for TE; these materials can be easily functionalized; they are self-healing, biodegradable, stimuli-responsive, and nonimmunogenic. These characteristics are vital for the further development of current trends in TE, such as the use of pluripotent cells for organoid generation, cell-free scaffolds for tissue regeneration, patient-derived organ models, and controlled delivery systems of small molecules. In this review, we will analyse the 3 subtypes of SBPs: peptide-, nucleic acid-, and oligosaccharide-derived. Then, we will discuss the role that SBPs will be playing in TE as dynamic scaffolds, therapeutic scaffolds, and bioinks. Finally, we will describe possible outlooks of SBPs for TE.http://dx.doi.org/10.1155/2021/8815006 |
| spellingShingle | Rosario Pérez-Pedroza Alan Ávila-Ramírez Zainab Khan Manola Moretti Charlotte A. E. Hauser Supramolecular Biopolymers for Tissue Engineering Advances in Polymer Technology |
| title | Supramolecular Biopolymers for Tissue Engineering |
| title_full | Supramolecular Biopolymers for Tissue Engineering |
| title_fullStr | Supramolecular Biopolymers for Tissue Engineering |
| title_full_unstemmed | Supramolecular Biopolymers for Tissue Engineering |
| title_short | Supramolecular Biopolymers for Tissue Engineering |
| title_sort | supramolecular biopolymers for tissue engineering |
| url | http://dx.doi.org/10.1155/2021/8815006 |
| work_keys_str_mv | AT rosarioperezpedroza supramolecularbiopolymersfortissueengineering AT alanavilaramirez supramolecularbiopolymersfortissueengineering AT zainabkhan supramolecularbiopolymersfortissueengineering AT manolamoretti supramolecularbiopolymersfortissueengineering AT charlotteaehauser supramolecularbiopolymersfortissueengineering |