ATR regulates OCT4 phosphorylation and safeguards human naïve pluripotency

ATR regulates OCT4 phosphorylation and safeguards human naïve pluripotency

Abstract Under specific conditions, cultured human embryonic stem cells (hESCs) corresponding to primed post-implantation epiblasts can be converted back to a ‘naïve pluripotency’ state that resembles the pre-implantation epiblasts. The core pluripotency factor OCT4 is known to be crucial in regulat...

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Bibliographic Details
Main Authors: Xudong Ma, Cheng Chen, Xinyu Chen, Songsong Dan, Jianqiong Li, Xiaobing Zhang, Shiqi She, Jianwen Hu, Yan-Wen Zhou, Bo Kang, Ying-Jie Wang, Wenjie Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
OCT4
ATR
Naïve pluripotency
Phosphoproteomics
Post-translational modification
Embryonic stem cells
Online Access:https://doi.org/10.1038/s41598-025-97829-z
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