Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI

Abstract A computational workflow integrating a stacked ensemble machine learning (SEML) model and a convolutional neural network (CNN) model with evolutionary algorithms has been developed to identify new compositions of FeNiCrCoCu MPEAs with high bulk modulus and unstable stacking fault energies....

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Main Authors: Fangxi Wang, Allana G. Iwanicki, Abhishek T. Sose, Lucas A. Pressley, Tyrel M. McQueen, Sanket A. Deshmukh
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Computational Materials
Online Access:https://doi.org/10.1038/s41524-025-01600-x
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author Fangxi Wang
Allana G. Iwanicki
Abhishek T. Sose
Lucas A. Pressley
Tyrel M. McQueen
Sanket A. Deshmukh
author_facet Fangxi Wang
Allana G. Iwanicki
Abhishek T. Sose
Lucas A. Pressley
Tyrel M. McQueen
Sanket A. Deshmukh
author_sort Fangxi Wang
collection DOAJ
description Abstract A computational workflow integrating a stacked ensemble machine learning (SEML) model and a convolutional neural network (CNN) model with evolutionary algorithms has been developed to identify new compositions of FeNiCrCoCu MPEAs with high bulk modulus and unstable stacking fault energies. The identified compositions were synthesized and tested for their crystal structures and mechanical properties (hardness and Young’s modulus), resulting in single-phase face-centered cubic (FCC) structures. Additionally, the measured Young’s moduli were in good qualitative agreement with computational predictions. The SHapley Additive exPlanations (SHAP) analysis of the SEML model revealed a relationship between elemental concentration and USFE. Meanwhile, SHAP analysis of the CNN models uncovered correlations between the local clustering of MPEA elements and their mechanical properties. This computational workflow, along with the fundamental insights gained, can be readily expanded and applied to the design of MPEAs with different elemental compositions, as well as to materials beyond MPEAs.
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issn 2057-3960
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series npj Computational Materials
spelling doaj-art-673abed0a4cf498285bdcfc4da31131b2025-08-20T01:51:30ZengNature Portfolionpj Computational Materials2057-39602025-05-0111111810.1038/s41524-025-01600-xExperimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AIFangxi Wang0Allana G. Iwanicki1Abhishek T. Sose2Lucas A. Pressley3Tyrel M. McQueen4Sanket A. Deshmukh5Department of Chemical Engineering, Virginia TechDepartment of Chemistry, Department of Materials Science and Engineering, Johns Hopkins UniversityDepartment of Chemical Engineering, Virginia TechDepartment of Chemistry, Department of Materials Science and Engineering, Johns Hopkins UniversityDepartment of Chemistry, Department of Materials Science and Engineering, Johns Hopkins UniversityDepartment of Chemical Engineering, Virginia TechAbstract A computational workflow integrating a stacked ensemble machine learning (SEML) model and a convolutional neural network (CNN) model with evolutionary algorithms has been developed to identify new compositions of FeNiCrCoCu MPEAs with high bulk modulus and unstable stacking fault energies. The identified compositions were synthesized and tested for their crystal structures and mechanical properties (hardness and Young’s modulus), resulting in single-phase face-centered cubic (FCC) structures. Additionally, the measured Young’s moduli were in good qualitative agreement with computational predictions. The SHapley Additive exPlanations (SHAP) analysis of the SEML model revealed a relationship between elemental concentration and USFE. Meanwhile, SHAP analysis of the CNN models uncovered correlations between the local clustering of MPEA elements and their mechanical properties. This computational workflow, along with the fundamental insights gained, can be readily expanded and applied to the design of MPEAs with different elemental compositions, as well as to materials beyond MPEAs.https://doi.org/10.1038/s41524-025-01600-x
spellingShingle Fangxi Wang
Allana G. Iwanicki
Abhishek T. Sose
Lucas A. Pressley
Tyrel M. McQueen
Sanket A. Deshmukh
Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI
npj Computational Materials
title Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI
title_full Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI
title_fullStr Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI
title_full_unstemmed Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI
title_short Experimentally validated inverse design of FeNiCrCoCu MPEAs and unlocking key insights with explainable AI
title_sort experimentally validated inverse design of fenicrcocu mpeas and unlocking key insights with explainable ai
url https://doi.org/10.1038/s41524-025-01600-x
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