NOD1-Mediated Mucosal Host Defense against Helicobacter pylori
Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2010/476482 |
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| _version_ | 1849413985171931136 |
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| author | Tomohiro Watanabe Naoki Asano Atsushi Kitani Ivan J. Fuss Tsutomu Chiba Warren Strober |
| author_facet | Tomohiro Watanabe Naoki Asano Atsushi Kitani Ivan J. Fuss Tsutomu Chiba Warren Strober |
| author_sort | Tomohiro Watanabe |
| collection | DOAJ |
| description | Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined. Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H. pylori. The detection of H. pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines. In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H. pylori infection of the stomach. |
| format | Article |
| id | doaj-art-67373bb686f64cce816a765b0963cfe8 |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-67373bb686f64cce816a765b0963cfe82025-08-20T03:33:58ZengWileyInternational Journal of Inflammation2042-00992010-01-01201010.4061/2010/476482476482NOD1-Mediated Mucosal Host Defense against Helicobacter pyloriTomohiro Watanabe0Naoki Asano1Atsushi Kitani2Ivan J. Fuss3Tsutomu Chiba4Warren Strober5Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USAMucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USAMucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USAMucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USADepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanMucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USAInfection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined. Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H. pylori. The detection of H. pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines. In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H. pylori infection of the stomach.http://dx.doi.org/10.4061/2010/476482 |
| spellingShingle | Tomohiro Watanabe Naoki Asano Atsushi Kitani Ivan J. Fuss Tsutomu Chiba Warren Strober NOD1-Mediated Mucosal Host Defense against Helicobacter pylori International Journal of Inflammation |
| title | NOD1-Mediated Mucosal Host Defense against Helicobacter pylori |
| title_full | NOD1-Mediated Mucosal Host Defense against Helicobacter pylori |
| title_fullStr | NOD1-Mediated Mucosal Host Defense against Helicobacter pylori |
| title_full_unstemmed | NOD1-Mediated Mucosal Host Defense against Helicobacter pylori |
| title_short | NOD1-Mediated Mucosal Host Defense against Helicobacter pylori |
| title_sort | nod1 mediated mucosal host defense against helicobacter pylori |
| url | http://dx.doi.org/10.4061/2010/476482 |
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