Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia
According to the 2008 revision of the World Health Organization (WHO) classification of myeloid malignancies, philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) include clonal, hematologic disorders such as polycythemia vera, primary myelofibrosis, and essential thrombocythemi...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2015-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=1;spage=3;epage=16;aulast=Agarwal |
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| author | M B Agarwal Hemant Malhotra Prantar Chakrabarti Neelam Varma Vikram Mathews Jina Bhattacharyya Tulika Seth K Gayathri Hari Menon P G Subramanian Ajay Sharma Maitreyee Bhattacharyya Jay Mehta A K Vaid Sandeep Shah Shyam Aggarwal P K Gogoi Reena Nair Usha Agarwal Subhash Varma S. V. S. S. Prasad Marie Therese Manipadam |
| author_facet | M B Agarwal Hemant Malhotra Prantar Chakrabarti Neelam Varma Vikram Mathews Jina Bhattacharyya Tulika Seth K Gayathri Hari Menon P G Subramanian Ajay Sharma Maitreyee Bhattacharyya Jay Mehta A K Vaid Sandeep Shah Shyam Aggarwal P K Gogoi Reena Nair Usha Agarwal Subhash Varma S. V. S. S. Prasad Marie Therese Manipadam |
| author_sort | M B Agarwal |
| collection | DOAJ |
| description | According to the 2008 revision of the World Health Organization (WHO) classification of myeloid malignancies, philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) include clonal, hematologic disorders such as polycythemia vera, primary myelofibrosis, and essential thrombocythemia. Recent years have witnessed major advances in the understanding of the molecular pathophysiology of these rare subgroups of chronic, myeloproliferative disorders. Identification of somatic mutations in genes associated with pathogenesis and evolution of these myeloproliferative conditions (Janus Kinase 2; myeloproliferative leukemia virus gene; calreticulin) led to substantial changes in the international guidelines for diagnosis and treatment of Ph-negative MPN during the last few years. The MPN-Working Group (MPN-WG), a panel of hematologists with expertise in MPN diagnosis and treatment from various parts of India, examined applicability of this latest clinical and scientific evidence in the context of hematology practice in India.This manuscript summarizes the consensus recommendations formulated by the MPN-WG that can be followed as a guideline for management of patients with Ph-negative MPN in the context of clinical practice in India. |
| format | Article |
| id | doaj-art-6733c059c79c4302af41c00d8d92838c |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-6733c059c79c4302af41c00d8d92838c2025-08-20T03:10:38ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512015-01-0136131610.4103/0971-5851.151770Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemiaM B AgarwalHemant MalhotraPrantar ChakrabartiNeelam VarmaVikram MathewsJina BhattacharyyaTulika SethK GayathriHari MenonP G SubramanianAjay SharmaMaitreyee BhattacharyyaJay MehtaA K VaidSandeep ShahShyam AggarwalP K GogoiReena NairUsha AgarwalSubhash VarmaS. V. S. S. PrasadMarie Therese ManipadamAccording to the 2008 revision of the World Health Organization (WHO) classification of myeloid malignancies, philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) include clonal, hematologic disorders such as polycythemia vera, primary myelofibrosis, and essential thrombocythemia. Recent years have witnessed major advances in the understanding of the molecular pathophysiology of these rare subgroups of chronic, myeloproliferative disorders. Identification of somatic mutations in genes associated with pathogenesis and evolution of these myeloproliferative conditions (Janus Kinase 2; myeloproliferative leukemia virus gene; calreticulin) led to substantial changes in the international guidelines for diagnosis and treatment of Ph-negative MPN during the last few years. The MPN-Working Group (MPN-WG), a panel of hematologists with expertise in MPN diagnosis and treatment from various parts of India, examined applicability of this latest clinical and scientific evidence in the context of hematology practice in India.This manuscript summarizes the consensus recommendations formulated by the MPN-WG that can be followed as a guideline for management of patients with Ph-negative MPN in the context of clinical practice in India.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=1;spage=3;epage=16;aulast=AgarwalEssential thrombocythemiamyeloproliferative neoplasmspolycythemia veraprimary myelofibrosis |
| spellingShingle | M B Agarwal Hemant Malhotra Prantar Chakrabarti Neelam Varma Vikram Mathews Jina Bhattacharyya Tulika Seth K Gayathri Hari Menon P G Subramanian Ajay Sharma Maitreyee Bhattacharyya Jay Mehta A K Vaid Sandeep Shah Shyam Aggarwal P K Gogoi Reena Nair Usha Agarwal Subhash Varma S. V. S. S. Prasad Marie Therese Manipadam Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia Indian Journal of Medical and Paediatric Oncology Essential thrombocythemia myeloproliferative neoplasms polycythemia vera primary myelofibrosis |
| title | Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia |
| title_full | Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia |
| title_fullStr | Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia |
| title_full_unstemmed | Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia |
| title_short | Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia |
| title_sort | myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis polycythemia vera and essential thrombocythemia |
| topic | Essential thrombocythemia myeloproliferative neoplasms polycythemia vera primary myelofibrosis |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=1;spage=3;epage=16;aulast=Agarwal |
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