Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration
The rapid corrosion rate and limited biological functionality still pose challenges for magnesium (Mg)-based implants in the treatment of complicated bone-related diseases in clinic. Herein, a multifunctional biodegradable curcumin (herbal medicine)-ferrum (Cur-Fe) nanoflower was self-assembled on p...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724000124 |
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| author | Huihui Du Dongdong Zhang Kui Xue Limin Ma Ru Xu Ji Tan Feng Peng Xuanyong Liu |
| author_facet | Huihui Du Dongdong Zhang Kui Xue Limin Ma Ru Xu Ji Tan Feng Peng Xuanyong Liu |
| author_sort | Huihui Du |
| collection | DOAJ |
| description | The rapid corrosion rate and limited biological functionality still pose challenges for magnesium (Mg)-based implants in the treatment of complicated bone-related diseases in clinic. Herein, a multifunctional biodegradable curcumin (herbal medicine)-ferrum (Cur-Fe) nanoflower was self-assembled on plasma electrolytic oxidation (PEO)-treated Mg alloy via a facile immersion process to realize differential biological function for anti-bacteria/tumor and bone regeneration. The results indicated that Cur-Fe nanoflower coating can promote protein adsorption, cell adhesion and proliferation, exhibiting excellent biocompatibility. The Cur-Fe nanoflower coating exhibits unique degradation characteristics, as curcumin gradually decomposes into ferulic acid, aromatic aldehyde and other antibacterial substances, and the coating spontaneously converts into FeOOH nanosheets, ensuring the corrosion resistance of Mg-based implants. Moreover, Cur-Fe coating exhibits remarkable narrow gap semiconductor characteristics, which can generate reactive oxygen species (ROS) and demonstrated excellent antibacterial effect under simulated sunlight (SSL) irradiation. Meanwhile, under NIR irradiation, Cur-Fe coating showed excellent chemotherapy/photodynamic/photothermal synergetic antitumor properties in vitro and in vivo due to the introduction of curcumin, and photocatalysis and photothermal conversion properties of coating. Furthermore, Cur-Fe nanoflower coating demonstrated great osteogenesis activity in vitro and in vivo due to unique micro/nano structure, surface chemical bond, and the release of Mg and Fe ions. |
| format | Article |
| id | doaj-art-6730c4f374a245368fdd74299901ff95 |
| institution | Kabale University |
| issn | 2213-9567 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-6730c4f374a245368fdd74299901ff952025-02-06T05:11:37ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672025-01-01131130147Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regenerationHuihui Du0Dongdong Zhang1Kui Xue2Limin Ma3Ru Xu4Ji Tan5Feng Peng6Xuanyong Liu7State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, ChinaShenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China; Corresponding authors.School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, ChinaMedical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510080, ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, ChinaMedical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510080, China; Corresponding authors.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, China; Corresponding authors.The rapid corrosion rate and limited biological functionality still pose challenges for magnesium (Mg)-based implants in the treatment of complicated bone-related diseases in clinic. Herein, a multifunctional biodegradable curcumin (herbal medicine)-ferrum (Cur-Fe) nanoflower was self-assembled on plasma electrolytic oxidation (PEO)-treated Mg alloy via a facile immersion process to realize differential biological function for anti-bacteria/tumor and bone regeneration. The results indicated that Cur-Fe nanoflower coating can promote protein adsorption, cell adhesion and proliferation, exhibiting excellent biocompatibility. The Cur-Fe nanoflower coating exhibits unique degradation characteristics, as curcumin gradually decomposes into ferulic acid, aromatic aldehyde and other antibacterial substances, and the coating spontaneously converts into FeOOH nanosheets, ensuring the corrosion resistance of Mg-based implants. Moreover, Cur-Fe coating exhibits remarkable narrow gap semiconductor characteristics, which can generate reactive oxygen species (ROS) and demonstrated excellent antibacterial effect under simulated sunlight (SSL) irradiation. Meanwhile, under NIR irradiation, Cur-Fe coating showed excellent chemotherapy/photodynamic/photothermal synergetic antitumor properties in vitro and in vivo due to the introduction of curcumin, and photocatalysis and photothermal conversion properties of coating. Furthermore, Cur-Fe nanoflower coating demonstrated great osteogenesis activity in vitro and in vivo due to unique micro/nano structure, surface chemical bond, and the release of Mg and Fe ions.http://www.sciencedirect.com/science/article/pii/S2213956724000124Magnesium-based implantsHerbal medicineCurcumin-ferrum nanoflowerAnti-bacterial/tumorOsteogenesis |
| spellingShingle | Huihui Du Dongdong Zhang Kui Xue Limin Ma Ru Xu Ji Tan Feng Peng Xuanyong Liu Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration Journal of Magnesium and Alloys Magnesium-based implants Herbal medicine Curcumin-ferrum nanoflower Anti-bacterial/tumor Osteogenesis |
| title | Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration |
| title_full | Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration |
| title_fullStr | Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration |
| title_full_unstemmed | Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration |
| title_short | Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration |
| title_sort | self assembled biodegradable herbal based nanoflower decorative magnesium implants combine therapy with bone regeneration |
| topic | Magnesium-based implants Herbal medicine Curcumin-ferrum nanoflower Anti-bacterial/tumor Osteogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724000124 |
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