The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine

The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine

Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, has been implicated in the pathogenesis of various chronic diseases, including cardiovascular, digestive, neurological, and renal disorders. This review explores the complex mechanisms by which TMAO contributes to disease progr...

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Main Authors: Zizhen Qin, Wanning Wu, Xinyu Yang, Xiao Wang, Anni Ding, Yueyi Huang, Jiaxuan Tang, Siyuan Jiang, Peng Zhang, Chenwei Qian, Xiangrui Zhang, Shihan Zhou, Yanqing Wang, Zhouchenghao Song, Minjie Sun, Mingqiang Wang, Shuang Shen, Boran Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
trimethylamine N-oxide
gut microbiota
chronic diseases
traditional Chinese medicine
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1592524/full
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