The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine
Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, has been implicated in the pathogenesis of various chronic diseases, including cardiovascular, digestive, neurological, and renal disorders. This review explores the complex mechanisms by which TMAO contributes to disease progr...
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| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1592524/full |
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| author | Zizhen Qin Wanning Wu Xinyu Yang Xiao Wang Anni Ding Yueyi Huang Jiaxuan Tang Siyuan Jiang Peng Zhang Chenwei Qian Xiangrui Zhang Shihan Zhou Yanqing Wang Zhouchenghao Song Minjie Sun Mingqiang Wang Mingqiang Wang Mingqiang Wang Shuang Shen Boran Zhu Boran Zhu Boran Zhu |
| author_facet | Zizhen Qin Wanning Wu Xinyu Yang Xiao Wang Anni Ding Yueyi Huang Jiaxuan Tang Siyuan Jiang Peng Zhang Chenwei Qian Xiangrui Zhang Shihan Zhou Yanqing Wang Zhouchenghao Song Minjie Sun Mingqiang Wang Mingqiang Wang Mingqiang Wang Shuang Shen Boran Zhu Boran Zhu Boran Zhu |
| author_sort | Zizhen Qin |
| collection | DOAJ |
| description | Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, has been implicated in the pathogenesis of various chronic diseases, including cardiovascular, digestive, neurological, and renal disorders. This review explores the complex mechanisms by which TMAO contributes to disease progression, including its role in inflammation, oxidative stress, and metabolic disorders. The study focused on the potential of traditional Chinese medicine (TCM) to regulate TMAO levels and mitigate its adverse effects. TCM interventions, through modulation of gut microbiota and inhibition of key enzymes like flavin-containing monooxygenase 3 (FMO3), offer promising therapeutic avenues. Despite the positive outcomes observed in preliminary studies, further research is needed to fully elucidate the mechanisms by which TCM interacts with TMAO and to establish its efficacy in clinical settings. |
| format | Article |
| id | doaj-art-672ef4962ff24158a8edfda3bf2eeae7 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-672ef4962ff24158a8edfda3bf2eeae72025-08-20T03:56:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15925241592524The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicineZizhen Qin0Wanning Wu1Xinyu Yang2Xiao Wang3Anni Ding4Yueyi Huang5Jiaxuan Tang6Siyuan Jiang7Peng Zhang8Chenwei Qian9Xiangrui Zhang10Shihan Zhou11Yanqing Wang12Zhouchenghao Song13Minjie Sun14Mingqiang Wang15Mingqiang Wang16Mingqiang Wang17Shuang Shen18Boran Zhu19Boran Zhu20Boran Zhu21Nanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaUnion Laboratory of Traditional Chinese Medicine for Brain Science and Gerontology, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Elderly Care Services and Management, Nanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaUnion Laboratory of Traditional Chinese Medicine for Brain Science and Gerontology, Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Association of Medicated Diet, Nanjing, ChinaTrimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, has been implicated in the pathogenesis of various chronic diseases, including cardiovascular, digestive, neurological, and renal disorders. This review explores the complex mechanisms by which TMAO contributes to disease progression, including its role in inflammation, oxidative stress, and metabolic disorders. The study focused on the potential of traditional Chinese medicine (TCM) to regulate TMAO levels and mitigate its adverse effects. TCM interventions, through modulation of gut microbiota and inhibition of key enzymes like flavin-containing monooxygenase 3 (FMO3), offer promising therapeutic avenues. Despite the positive outcomes observed in preliminary studies, further research is needed to fully elucidate the mechanisms by which TCM interacts with TMAO and to establish its efficacy in clinical settings.https://www.frontiersin.org/articles/10.3389/fphar.2025.1592524/fulltrimethylamine N-oxidegut microbiotachronic diseasestraditional Chinese medicineinflammationoxidative stress |
| spellingShingle | Zizhen Qin Wanning Wu Xinyu Yang Xiao Wang Anni Ding Yueyi Huang Jiaxuan Tang Siyuan Jiang Peng Zhang Chenwei Qian Xiangrui Zhang Shihan Zhou Yanqing Wang Zhouchenghao Song Minjie Sun Mingqiang Wang Mingqiang Wang Mingqiang Wang Shuang Shen Boran Zhu Boran Zhu Boran Zhu The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine Frontiers in Pharmacology trimethylamine N-oxide gut microbiota chronic diseases traditional Chinese medicine inflammation oxidative stress |
| title | The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine |
| title_full | The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine |
| title_fullStr | The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine |
| title_full_unstemmed | The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine |
| title_short | The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine |
| title_sort | role of trimethylamine n oxide in disease pathogenesis and the therapeutic potential of traditional chinese medicine |
| topic | trimethylamine N-oxide gut microbiota chronic diseases traditional Chinese medicine inflammation oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1592524/full |
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