Isoniazid preventive therapy modulates Mycobacterium tuberculosis-specific T-cell responses in individuals with latent tuberculosis and type 2 diabetes

Isoniazid preventive therapy modulates Mycobacterium tuberculosis-specific T-cell responses in individuals with latent tuberculosis and type 2 diabetes

Abstract Diabetes mellitus (DM) is a significant contributor to tuberculosis (TB) incidence and poor treatment outcomes. This study explored the impact of isoniazid preventive therapy (IPT) on Mycobacterium tuberculosis (Mtb)-specific T-cell memory phenotypes and function among participants with lat...

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Main Authors: Phillip Ssekamatte, Diana Sitenda, Rose Nabatanzi, Marjorie Nakibuule, Davis Kibirige, Andrew Peter Kyazze, David Patrick Kateete, Bernard Ssentalo Bagaya, Obondo James Sande, Reinout van Crevel, Stephen Cose, Irene Andia Biraro
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Latent TB infection
Diabetes
T cells
Isoniazid preventive treatment
Memory phenotypes
Functional profiles
Online Access:https://doi.org/10.1038/s41598-025-95386-z
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