Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer
Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in DNA replication and genome stability. FEN1 is overexpressed in proliferative cancers and correlates with the grade and aggressiveness of the cancer, suggesting that it could potentially be considered a promising biomark...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053924000869 |
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| author | Saba Mahboubi Mehdi Evazalipour Ehsan Zamani Nozhat Zebardast Alireza Farokhrouz Rahim Nosrati |
| author_facet | Saba Mahboubi Mehdi Evazalipour Ehsan Zamani Nozhat Zebardast Alireza Farokhrouz Rahim Nosrati |
| author_sort | Saba Mahboubi |
| collection | DOAJ |
| description | Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in DNA replication and genome stability. FEN1 is overexpressed in proliferative cancers and correlates with the grade and aggressiveness of the cancer, suggesting that it could potentially be considered a promising biomarker for various cancer types. Due to the initiation of cancer is related to the lack of the activity of FEN1 nuclease, the detection and quantification of FEN1 is significance for cancer diagnosis in early stage. There are various approaches to detect the different types of cancer biomarkers. In this context, biosensing platforms and nanotechnology-based methods have attracted much attention. To date, the sensitivity and performance of biosensors can enhance by nanomaterials/nanoparticles that have been incorporated in biosensing platforms. This review overview a brief classification and description of the advancement of biosensors and nanobiosensors for the detection and quantitation of FEN1 based on optical and electrochemical platforms. |
| format | Article |
| id | doaj-art-672ab9089c5b4abab4c3cfb07418cdce |
| institution | OA Journals |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-672ab9089c5b4abab4c3cfb07418cdce2025-08-20T02:37:51ZengElsevierSensors and Actuators Reports2666-05392025-06-01910027010.1016/j.snr.2024.100270Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancerSaba Mahboubi0Mehdi Evazalipour1Ehsan Zamani2Nozhat Zebardast3Alireza Farokhrouz4Rahim Nosrati5Institute for Molecular Medicine, Paul Klein Center for Immune Intervention, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Department of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, IranDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, IranCellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran; Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, IranCellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Corresponding author at: Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in DNA replication and genome stability. FEN1 is overexpressed in proliferative cancers and correlates with the grade and aggressiveness of the cancer, suggesting that it could potentially be considered a promising biomarker for various cancer types. Due to the initiation of cancer is related to the lack of the activity of FEN1 nuclease, the detection and quantification of FEN1 is significance for cancer diagnosis in early stage. There are various approaches to detect the different types of cancer biomarkers. In this context, biosensing platforms and nanotechnology-based methods have attracted much attention. To date, the sensitivity and performance of biosensors can enhance by nanomaterials/nanoparticles that have been incorporated in biosensing platforms. This review overview a brief classification and description of the advancement of biosensors and nanobiosensors for the detection and quantitation of FEN1 based on optical and electrochemical platforms.http://www.sciencedirect.com/science/article/pii/S2666053924000869Flap endonuclease 1 (FEN1)BiosensorNanosensorCancer biomarkerCRISPR/Cas12a |
| spellingShingle | Saba Mahboubi Mehdi Evazalipour Ehsan Zamani Nozhat Zebardast Alireza Farokhrouz Rahim Nosrati Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer Sensors and Actuators Reports Flap endonuclease 1 (FEN1) Biosensor Nanosensor Cancer biomarker CRISPR/Cas12a |
| title | Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer |
| title_full | Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer |
| title_fullStr | Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer |
| title_full_unstemmed | Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer |
| title_short | Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer |
| title_sort | flap endonuclease 1 fen1 biomarker as a new diagnostic target for the biosensing of cancer |
| topic | Flap endonuclease 1 (FEN1) Biosensor Nanosensor Cancer biomarker CRISPR/Cas12a |
| url | http://www.sciencedirect.com/science/article/pii/S2666053924000869 |
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