Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration
Abstract Low back pain caused by intervertebral disc degeneration (IDD) has emerged as a significant global public health concern, with far-reaching consequences for patients' quality of life and healthcare systems. Although previous research have revealed that the mechanisms of intervertebral...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-024-05280-z |
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| author | Heng Chen Tian Tang Congyang Xue Xin Liu Zhipeng Xi Lin Xie Ran Kang |
| author_facet | Heng Chen Tian Tang Congyang Xue Xin Liu Zhipeng Xi Lin Xie Ran Kang |
| author_sort | Heng Chen |
| collection | DOAJ |
| description | Abstract Low back pain caused by intervertebral disc degeneration (IDD) has emerged as a significant global public health concern, with far-reaching consequences for patients' quality of life and healthcare systems. Although previous research have revealed that the mechanisms of intervertebral disc cell apoptosis, pyroptosis and necroptosis can aggravate IDD damage by mediating inflammation and promoting extracellular matrix degradation, but they cannot explain the connection between different cell death mechanisms and ion metabolism disorders. The latest study shows that cell death mechanisms such as cellular senescence, ferroptosis, and cuproptosis, and PANopotosis have similar roles in the progression of intervertebral disc degeneration, but not exactly the same damage mechanism. This paper summarizes the effects of various cell death patterns on the disease progression of IDD, related molecular mechanisms and signaling pathways, providing new perspectives and potential clinical intervention strategies for the prevention and treatment of IDD. |
| format | Article |
| id | doaj-art-672836bfd2b24d9e89bde5d3a5fd84a5 |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-672836bfd2b24d9e89bde5d3a5fd84a52024-12-08T12:37:48ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2024-12-0119111510.1186/s13018-024-05280-zExploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degenerationHeng Chen0Tian Tang1Congyang Xue2Xin Liu3Zhipeng Xi4Lin Xie5Ran Kang6Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAbstract Low back pain caused by intervertebral disc degeneration (IDD) has emerged as a significant global public health concern, with far-reaching consequences for patients' quality of life and healthcare systems. Although previous research have revealed that the mechanisms of intervertebral disc cell apoptosis, pyroptosis and necroptosis can aggravate IDD damage by mediating inflammation and promoting extracellular matrix degradation, but they cannot explain the connection between different cell death mechanisms and ion metabolism disorders. The latest study shows that cell death mechanisms such as cellular senescence, ferroptosis, and cuproptosis, and PANopotosis have similar roles in the progression of intervertebral disc degeneration, but not exactly the same damage mechanism. This paper summarizes the effects of various cell death patterns on the disease progression of IDD, related molecular mechanisms and signaling pathways, providing new perspectives and potential clinical intervention strategies for the prevention and treatment of IDD.https://doi.org/10.1186/s13018-024-05280-zIntervertebral disc degenerationCell death modeApoptosisPyroptosisNecroptosisCell senescence |
| spellingShingle | Heng Chen Tian Tang Congyang Xue Xin Liu Zhipeng Xi Lin Xie Ran Kang Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration Journal of Orthopaedic Surgery and Research Intervertebral disc degeneration Cell death mode Apoptosis Pyroptosis Necroptosis Cell senescence |
| title | Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration |
| title_full | Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration |
| title_fullStr | Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration |
| title_full_unstemmed | Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration |
| title_short | Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration |
| title_sort | exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration |
| topic | Intervertebral disc degeneration Cell death mode Apoptosis Pyroptosis Necroptosis Cell senescence |
| url | https://doi.org/10.1186/s13018-024-05280-z |
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