Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

Abstract Drug resistance remains a major obstacle in treating pancreatic ductal adenocarcinoma (PDAC). Nuclear protein 1 (NUPR1), a stress-responsive protein implicated in cancer progression and treatment resistance, represents a potential therapeutic target. Our laboratory has developed NUPR1 inhib...

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Bibliographic Details
Main Authors: Patricia Santofimia-Castaño, Wenjun Lan, Matias Estaras, Yi Xia, Emma Cosialls, Nicolas Fraunhoffer, Ling Peng, Eduardo Chuluyan, Juan Iovanna
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-11931-w
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