High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes
Background. Impairments of endocrine system may be associated with exposure to perfluorinated compounds that are able to bind nuclear receptors, including the peroxisome proliferator-activating receptors. Aim of this study was to assess perfluorooctane sulfonate and perfluorooctanoic acid concentrat...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/234358 |
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| author | Barbara Predieri Lorenzo Iughetti Cristiana Guerranti Patrizia Bruzzi Guido Perra Silvano E. Focardi |
| author_facet | Barbara Predieri Lorenzo Iughetti Cristiana Guerranti Patrizia Bruzzi Guido Perra Silvano E. Focardi |
| author_sort | Barbara Predieri |
| collection | DOAJ |
| description | Background. Impairments of endocrine system may be associated with exposure to perfluorinated compounds that are able to bind nuclear receptors, including the peroxisome proliferator-activating receptors. Aim of this study was to assess perfluorooctane sulfonate and perfluorooctanoic acid concentrations in children and adolescents at the onset of type 1 diabetes compared to healthy controls. Methods. Forty-four children and adolescents were recruited and subdivided into two groups: (A) 25 subjects with type 1 diabetes and (B) 19 healthy controls. Perfluorinated compounds were measured using high performance liquid chromatography with electrospray ionization tandem mass spectrometry. Nonparametric statistical analysis was performed. Results. Perfluorooctane sulfonate concentrations were significantly higher in patients with type 1 diabetes compared to controls (1.53 ± 1.50 versus 0.55 ± 0.15 ng/mL, resp.; p<0.001). Multivariate linear regression analysis identified lipid levels as significant predictive factors for perfluorooctane sulfonate levels. Conclusions. Our data suggests that higher serum levels of perfluorooctane sulfonate may be considered a biomarker of exposure and susceptibility to develop type 1 diabetes. |
| format | Article |
| id | doaj-art-6719257533f2456696c46dd74c7447aa |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6719257533f2456696c46dd74c7447aa2025-02-03T01:02:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/234358234358High Levels of Perfluorooctane Sulfonate in Children at the Onset of DiabetesBarbara Predieri0Lorenzo Iughetti1Cristiana Guerranti2Patrizia Bruzzi3Guido Perra4Silvano E. Focardi5Department of Medical and Surgical Sciences of the Mother, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences of the Mother, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Environmental Sciences “G. Sarfatti”, University of Siena, 53100 Siena, ItalyDepartment of Medical and Surgical Sciences of the Mother, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Environmental Sciences “G. Sarfatti”, University of Siena, 53100 Siena, ItalyDepartment of Environmental Sciences “G. Sarfatti”, University of Siena, 53100 Siena, ItalyBackground. Impairments of endocrine system may be associated with exposure to perfluorinated compounds that are able to bind nuclear receptors, including the peroxisome proliferator-activating receptors. Aim of this study was to assess perfluorooctane sulfonate and perfluorooctanoic acid concentrations in children and adolescents at the onset of type 1 diabetes compared to healthy controls. Methods. Forty-four children and adolescents were recruited and subdivided into two groups: (A) 25 subjects with type 1 diabetes and (B) 19 healthy controls. Perfluorinated compounds were measured using high performance liquid chromatography with electrospray ionization tandem mass spectrometry. Nonparametric statistical analysis was performed. Results. Perfluorooctane sulfonate concentrations were significantly higher in patients with type 1 diabetes compared to controls (1.53 ± 1.50 versus 0.55 ± 0.15 ng/mL, resp.; p<0.001). Multivariate linear regression analysis identified lipid levels as significant predictive factors for perfluorooctane sulfonate levels. Conclusions. Our data suggests that higher serum levels of perfluorooctane sulfonate may be considered a biomarker of exposure and susceptibility to develop type 1 diabetes.http://dx.doi.org/10.1155/2015/234358 |
| spellingShingle | Barbara Predieri Lorenzo Iughetti Cristiana Guerranti Patrizia Bruzzi Guido Perra Silvano E. Focardi High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes International Journal of Endocrinology |
| title | High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes |
| title_full | High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes |
| title_fullStr | High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes |
| title_full_unstemmed | High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes |
| title_short | High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes |
| title_sort | high levels of perfluorooctane sulfonate in children at the onset of diabetes |
| url | http://dx.doi.org/10.1155/2015/234358 |
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